1. The CSF Levels of Neutrophil-Related Chemokines in Patients with Neuromyelitis Optica.
- Author
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Liu Z, Chen J, Wang Z, Wang Y, Zheng D, Wang H, and Peng Y
- Subjects
- Adult, Female, Humans, Male, Middle Aged, Neuromyelitis Optica physiopathology, Severity of Illness Index, Chemokine CXCL1 cerebrospinal fluid, Chemokine CXCL5 cerebrospinal fluid, Neuromyelitis Optica cerebrospinal fluid, Neutrophil Activation, beta-Thromboglobulin cerebrospinal fluid
- Abstract
Pathologic findings showed that neutrophils played an important role in the pathogenesis of NMO. This study aims to investigate the CSF levels of neutrophil-related chemokines in NMO. CXCL1, CXCL5, and CXCL7 were measured in 95 patients with NMO, 15 patients with MS, 18 patients with GFAP astrocytopathy, and 16 controls. The CSF level of CXCL1, CXCL5, and CXCL7 was significantly elevated in the NMO group but not correlated with the patient clinical severity. Besides, the CSF CXCL1, CXCL5, and CXCL7 could act as biomarkers to distinguish NMO from MS with good reliability, especially the CXCL7., (© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.)
- Published
- 2020
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