9 results on '"Barbaud A"'
Search Results
2. Allergic contact dermatitis caused by PEG‐22 and PEG‐45 dodecyl glycol copolymers in two skin‐repairing creams.
- Author
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Brehon, Alice, Soria, Angèle, Barbaud, Annick, and Amsler, Emmanuelle
- Subjects
ETHYLENE glycol ,CONTACT dermatitis ,COPOLYMERS ,GLYCOLS ,ECZEMA ,BENZYL alcohol - Abstract
Keywords: allergic contact dermatitis; CAS no. 78336-31-9; case report; copolymers; cosmetic products; PEG-22/dodecyl glycol copolymer; PEG-45/dodecyl glycol copolymer EN allergic contact dermatitis CAS no. 78336-31-9 case report copolymers cosmetic products PEG-22/dodecyl glycol copolymer PEG-45/dodecyl glycol copolymer 213 215 3 08/04/23 20230901 NES 230901 We report a case of allergic contact dermatitis (ACD) caused by PEG-22/dodecyl glycol copolymer and PEG-45/dodecyl glycol copolymer contained in two different "skin-repairing" creams. Allergic contact dermatitis, CAS no. 78336-31-9, case report, copolymers, cosmetic products, PEG-22/dodecyl glycol copolymer, PEG-45/dodecyl glycol copolymer Allergic contact dermatitis caused by PEG-22 and PEG-45 dodecyl glycol copolymers in two skin-repairing creams. [Extracted from the article]
- Published
- 2023
- Full Text
- View/download PDF
3. Multiple cases of sensitization to an antiseptic containing chlorhexidine digluconate/benzalkonium chloride/benzyl alcohol with different profiles of sensitization in adults and children
- Author
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Charlotte, Beaumont, Anne-Sophie, Darrigade, Annick, Barbaud, Evelyne, Collet, Nadia, Raison-Peyron, Jean-Luc, Bourrain, Haudrey, Assier, Françoise, Giordano-Labadie, Corina, Bara-Passot, Brigitte, Milpied, Florence, Tétart, Pierre, Armingaud, Florence, Castelain, Lamia, Benkalfate, Claire, Boulard, Juliette, Delaunay, Pascale, Mathelier-Fusade, Catherine, Pecquet, Pauline, Pralong, Dominique, Vital-Durand, Nathalie, Genillier Foin, Marine-Alexia, Lefèvre, Florence, Hacard, Audrey, Nosbaum, Justine, Pasteur, Aude, Valois, Martine, Vigan, Marie-Christine, Ferrier le Bouëdec, Service de dermatologie et allergologie [CHU Tenon], CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Dermatologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), CHU Montpellier, Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Service de dermatologie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Toulouse [Toulouse], CHU Bordeaux [Bordeaux], Service de Dermatologie [Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Service de pneumologie, allergologie, mucoviscidose pédiatrique [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service de dermatologie, hôpital Jacques-Monod, Le Havre, Département d'allergie et d'immunologie clinique [CHU Lyon Sud], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
- Subjects
recidal-gerda ,Adult ,Chlorhexidine ,contact dermatitis ,Dermatology ,Allergens ,Patch Tests ,allergy ,benzalkonium chloride ,Chlorides ,antiseptic ,Dermatitis, Allergic Contact ,Anti-Infective Agents, Local ,Humans ,Immunology and Allergy ,Benzalkonium Compounds ,Child ,ComputingMilieux_MISCELLANEOUS ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Benzyl Alcohols ,benzyl alcohol ,Retrospective Studies - Abstract
An aqueous antiseptic containing "chlorhexidine digluconate/benzalkonium chloride/benzyl alcohol" (CBB) is widely used in France. The only previous documented study dealing with allergic contact dermatitis (ACD) to this antiseptic is one small case series in children. The French Vigilance Network for Dermatology and Allergy (REVIDAL-GERDA) has collected many cases in the last few years.To evaluate the clinical and sensitization profiles of patients diagnosed with ACD to CBB.We performed a retrospective study of patients with contact dermatitis to CBB and positive tests to CBB and/or at least one of its components. All patients had to be tested with all components of CBB.A total of 102 patients (71 adults and 31 children) were included. The lesions were extensive in 63% of patients and 55% had delayed time to diagnosis. CBB patch tests were positive in 93.8% of cases. The allergen was identified in 97% of patients, mainly benzyl alcohol in adults (81.7%) and chlorhexidine digluconate in children (54.8%). About 32.4% of the patients were sensitized to several components.CBB is a cause of ACD at all ages. The components of the antiseptic should be tested. The sensitization profile seems to be different between adults and children.
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- 2022
4. Multiple cases of sensitization to an antiseptic containing chlorhexidine digluconate/benzalkonium chloride/benzyl alcohol with different profiles of sensitization in adults and children.
- Author
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Beaumont, Charlotte, Darrigade, Anne‐Sophie, Barbaud, Annick, Collet, Evelyne, Raison‐Peyron, Nadia, Bourrain, Jean‐Luc, Assier, Haudrey, Giordano‐Labadie, Françoise, Bara‐Passot, Corina, Milpied, Brigitte, Tétart, Florence, Armingaud, Pierre, Castelain, Florence, Benkalfate, Lamia, Boulard, Claire, Delaunay, Juliette, Mathelier‐Fusade, Pascale, Pecquet, Catherine, Pralong, Pauline, and Vital‐Durand, Dominique
- Subjects
CHLORHEXIDINE ,BENZYL alcohol ,BENZALKONIUM chloride ,ANTISEPTICS ,CONTACT dermatitis - Abstract
Background: An aqueous antiseptic containing "chlorhexidine digluconate/benzalkonium chloride/benzyl alcohol" (CBB) is widely used in France. The only previous documented study dealing with allergic contact dermatitis (ACD) to this antiseptic is one small case series in children. The French Vigilance Network for Dermatology and Allergy (REVIDAL‐GERDA) has collected many cases in the last few years. Objectives: To evaluate the clinical and sensitization profiles of patients diagnosed with ACD to CBB. Methods: We performed a retrospective study of patients with contact dermatitis to CBB and positive tests to CBB and/or at least one of its components. All patients had to be tested with all components of CBB. Results: A total of 102 patients (71 adults and 31 children) were included. The lesions were extensive in 63% of patients and 55% had delayed time to diagnosis. CBB patch tests were positive in 93.8% of cases. The allergen was identified in 97% of patients, mainly benzyl alcohol in adults (81.7%) and chlorhexidine digluconate in children (54.8%). About 32.4% of the patients were sensitized to several components. Conclusion: CBB is a cause of ACD at all ages. The components of the antiseptic should be tested. The sensitization profile seems to be different between adults and children. [ABSTRACT FROM AUTHOR]
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- 2022
- Full Text
- View/download PDF
5. Antimicrobial Preservatives for Protein and Peptide Formulations: An Overview.
- Author
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Stroppel, Luisa, Schultz-Fademrecht, Torsten, Cebulla, Martin, Blech, Michaela, Marhöfer, Richard J., Selzer, Paul M., and Garidel, Patrick
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ANTIMICROBIAL preservatives ,PEPTIDES ,PROTEINS ,PACKAGING materials ,MICROBIAL growth - Abstract
Biological drugs intended for multi-dose application require the presence of antimicrobial preservatives to avoid microbial growth. As the presence of certain preservatives has been reported to increase protein and peptide particle formation, it is essential to choose a preservative compatible with the active pharmaceutical ingredient in addition to its preservation function. Thus, this review describes the current status of the use of antimicrobial preservatives in biologic formulations considering (i) appropriate preservatives for protein and peptide formulations, (ii) their physico-chemical properties, (iii) their in-/compatibilities with other excipients or packaging material, and (iv) their interactions with the biological compound. Further, (v) we present an overview of licensed protein and peptide formulations. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
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6. Allergic contact dermatitis to chlorhexidine‐containing antiseptics and their excipients in children: A series of six cases.
- Author
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Kefala, Kalomoira and Ponvert, Claude
- Subjects
CONTACT dermatitis ,ANTISEPTICS ,BENZYL alcohol ,EXCIPIENTS ,BENZALKONIUM chloride ,ECZEMA - Abstract
Contact allergy to skin disinfectants is not often recognized in children. We report the cases of six children (1–16.5 years old) with allergic contact dermatitis to ingredients commonly contained in commercial antiseptic and cosmetic products. Patch test responses to chlorhexidine, benzyl alcohol, and benzalkonium chloride varied from one child to another one, but most children were sensitized to at least two components. In several of the cases, exposure had initially occurred in the neonatal period, but diagnosis occurred only after multiple reactions of increasing severity. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
7. Chlorhexidine anaphylaxis in three children secondary to oral exposure without evidence of mucosal breach.
- Author
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Wanin, Stephanie, Baron, Marguerite, Carra, Sophie, Saf, Sarah, Bourgoin‐Heck, Mélisande, and Chiriac, Anca Mirela
- Subjects
CHLORHEXIDINE ,ANAPHYLAXIS ,MILK allergy ,ATOPY ,ALLERGIES ,BENZYL alcohol ,ATOPIC dermatitis - Abstract
Chlorhexidine is a synthetic antiseptic of the biguanide family, with a broad spectrum of antibacterial action. Chlorhexidine allergy was confirmed with at least two confirmatory tests: positive prick or intradermal test and positive chlorhexidine serum-specific IgE (ImmunoCap ThermoFischer Scientific, Uppsala, Sweden: positive chlorhexidine threshold was defined as equal or above 0.1 kUA/L). Chlorhexidine allergy diagnosis was confirmed by prick testing and positive chlorhexidine-specific serum IgE. [Extracted from the article]
- Published
- 2022
- Full Text
- View/download PDF
8. Allergic contact dermatitis from benzyl alcohol mimicking acute generalized exanthematous pustulosis.
- Author
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Traineau, Hélène, Benassaia, Erwin, Diaz, Emmanuelle, Ingen‐Housz‐Oro, Saskia, and Assier, Haudrey
- Subjects
BENZYL alcohol ,DRUG eruptions ,CONTACT dermatitis ,ECZEMA ,CHLORHEXIDINE ,DRUGS - Abstract
(D) Pustular patch-test reactions (++) on day (D)3 to (benzyl alcohol-containing) Amycor cream "as is" (Merck Serono SAS, Lyon, France), to (benzyl alcohol-containing) Terbinafine cream "as is", and to benzyl alcohol 10% sof. Keywords: acute generalized exanthematous pustulosis; AGEP; allergic contact dermatitis; benzyl alcohol; CAS no. 100-51-6; case report EN acute generalized exanthematous pustulosis AGEP allergic contact dermatitis benzyl alcohol CAS no. 100-51-6 case report 100 102 3 06/14/22 20220701 NES 220701 Benzyl alcohol is a preservative often used in topical drugs and cosmetics and occasionally responsible for allergic contact dermatitis (ACD).1 We report a peculiar case of ACD from benzyl alcohol mimicking acute generalized exanthematous pustulosis (AGEP), which highlights that common topical drug excipients may occasionally be important culprit sensitizers. [Extracted from the article]
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- 2022
- Full Text
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9. Re‐evaluation of benzyl alcohol (E 1519) as food additive.
- Author
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Younes, Maged, Aquilina, Gabriele, Castle, Laurence, Engel, Karl‐Heinz, Fowler, Paul, Fürst, Peter, Gürtler, Rainer, Gundert‐Remy, Ursula, Husøy, Trine, Mennes, Wim, Moldeus, Peter, Oskarsson, Agneta, Shah, Romina, Waalkens‐Berendsen, Ine, Wölfle, Detlef, Boon, Polly, Crebelli, Riccardo, Di Domenico, Alessandro, Filipič, Metka, and Mortensen, Alicja
- Subjects
BENZYL alcohol ,FOOD additives ,BODY weight ,CARCINOGENICITY ,GENETIC toxicology - Abstract
The Panel on Food Additives and Flavourings (FAF) provided a scientific opinion re‐evaluating the safety of benzyl alcohol (E 1519) when used as a food additive. The Panel considered that adequate exposure and toxicity data were available. Benzyl alcohol (E 1519) is authorised as a food additive in the EU in accordance with Annex III to Regulation (EC) No 1333/2008. The Panel considered benzyl alcohol of low acute toxicity with no concern with respect to genotoxicity and carcinogenicity and established an acceptable daily intake (ADI) of 4 mg/kg body weight (bw) per day based on a no observable adverse effect level (NOAEL) of 400 mg/kg bw per day from the carcinogenicity study in rats. The mean and high exposure estimates in the refined exposure scenarios were maximally 0.27 and 0.81 mg/kg bw per day in toddlers, respectively. The exposure estimates to benzyl alcohol (E 1519) were below the ADI of 4 mg/kg bw per day in all population groups. The Panel noted that also the exposure in the regulatory maximum level exposure assessment scenario is below the ADI in all population groups. The Panel concluded that the exposure to benzyl alcohol (E 1519) does not raise a safety concern at the reported uses and use levels. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
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