1. Tenofovir-emtricitabine-efavirenz in HIV-I-infected adults in Senegal: a 96-week pilot trial in treatment-naive patients.
- Author
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Landman R, Poupard M, Diallo M, Ngom Gueye NF, Diakhate N, Ndiaye B, Toure Kane C, Trylesinski A, Diop H, Mboup S, Koita Fall MB, Delaporte E, Benalycherif A, Girard PM, and Sow PS
- Subjects
- Adenine pharmacology, Adenine therapeutic use, Adult, Alkynes, Anti-HIV Agents pharmacology, Benzoxazines pharmacology, CD4 Lymphocyte Count, Cyclopropanes, Deoxycytidine pharmacology, Deoxycytidine therapeutic use, Drug Therapy, Combination, Emtricitabine, Female, HIV Infections immunology, HIV Infections psychology, Humans, Male, Medication Adherence, Middle Aged, Organophosphonates pharmacology, Pilot Projects, Quality of Life, RNA, Viral blood, Senegal, Tenofovir, Adenine analogs & derivatives, Anti-HIV Agents therapeutic use, Benzoxazines therapeutic use, Deoxycytidine analogs & derivatives, HIV Infections drug therapy, HIV-1 drug effects, Organophosphonates therapeutic use
- Abstract
We report the results of a pilot open-label trial of a tenofovir (TDF)/emtricitabine (FTC)/efavirenz (EFV) combination conducted in Dakar, Senegal. Forty HIV-1-infected patients, naive of antiretroviral treatment and without active opportunistic disease, were included and followed through 96 weeks. At weeks 48 and 96, respectively, 82.5% and 85% of patients had HIV-1 RNA <400 copies/mL (72.5% and 77.5% with HIV-1 RNA <50 copies/mL). Between baseline and week 96, the mean (SD) CD4 count increased from 126 (102) to 338 (155) cells/mm(3). The mean (SD) creatinine clearance decreased from 92 (36) to 73 (19) mL/min (P = .001). Treatment adherence was at least 94% at all scheduled visits. The efficacy and tolerability of a TDF/FTC/EFV combination were high and similar to those observed in Northern countries. This drug combination can be recommended in limited-resource countries, as did the World Health Organization (WHO) and should be made readily available as a fixed-dose combination.
- Published
- 2009
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