1. New Benzaldehyde and Benzopyran Compounds from the Endophytic Fungus Paraphaeosphaeria sp. F03 and Their Antimicrobial and Cytotoxic Activities.
- Author
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de Amorim MR, Hilário F, Dos Santos FM Junior, Batista JM Junior, Bauab TM, Araújo AR, Carlos IZ, Vilegas W, and Dos Santos LC
- Subjects
- Animals, Anti-Bacterial Agents chemistry, Antifungal Agents chemistry, Antifungal Agents isolation & purification, Benzaldehydes chemistry, Benzaldehydes isolation & purification, Benzopyrans chemistry, Benzopyrans isolation & purification, Cell Line, Tumor, Cytotoxins chemistry, Cytotoxins isolation & purification, Endophytes, Humans, Magnetic Resonance Spectroscopy, Mass Spectrometry, Mice, Microbial Sensitivity Tests, Molecular Structure, Anti-Bacterial Agents pharmacology, Antifungal Agents pharmacology, Ascomycota chemistry, Benzaldehydes pharmacology, Benzopyrans pharmacology, Cytotoxins pharmacology
- Abstract
Three new benzaldehyde derivatives, sporulosaldeins A - C (1: -3: ), and 3 new benzopyran derivatives, sporulosaldeins D - F (4: -6: ), were discovered from an endophytic fungus, Paraphaeosphaeria sp. F03, which was isolated from Paepalanthus planifolius leaves. Compounds 1: -6: were elucidated by 1- and 2-dimensional nuclear magnetic resonance experiments and high-resolution mass spectrometry analysis. The absolute configuration of compound 5: was determined through the comparison of experimental and calculated electronic circular dichroism data. Compounds 1: -6: were found to exhibit antifungal activity with minimum inhibitory concentration (MIC) values of 7.8 - 250 µg/mL and racemic mixture of compound 6: exhibited weak cytotoxicity against MCF-7 and LM3 with IC
50 values of 34.4 and 39.2 µM, respectively., Competing Interests: The authors declare no conflict of interest., (Georg Thieme Verlag KG Stuttgart · New York.)- Published
- 2019
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