1. [Triclabendazole (Fasinex) residue in milk: determination and excretion kinetics].
- Author
-
Counotte GH, Reimink A, Redder B, and Hasselt H
- Subjects
- Animals, Benzimidazoles pharmacokinetics, Benzimidazoles urine, Chromatography, High Pressure Liquid, Female, Triclabendazole, Anthelmintics analysis, Benzimidazoles analysis, Cattle metabolism, Drug Residues analysis, Milk chemistry
- Abstract
The determination of triclabendazole (Fasinex) in milk is described. The excretion of triclabendazole and its two main metabolites was measured under field conditions in twenty-five cows. Triclabendazole was administered to cows in a dosage of approximately 12 mg kg-1. The maximum concentration of the main metabolites of triclabendazole (triclabendzole sulphone) measured in milk was 1.415 mg/l. Metabolites could be detected in milk during a ten-day-period. Only 1.5% (maximum) of the triclabendazole administered was eliminated as triclabendazole sulphone by way of milk.
- Published
- 1990