1. The connectome of the adult Drosophila mushroom body provides insights into function
- Author
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Jack W Lindsey, Philipp Schlegel, Louis K. Scheffer, Audrey Francis, Marta Costa, Markus William Pleijzier, Feng Li, Nils Otto, Scott Waddell, Shin-ya Takemura, Gregory S.X.E. Jefferis, Ashok Litwin-Kumar, Alexander Shakeel Bates, Amalia Braun, Larry F. Abbott, Georgia Dempsey, Elizabeth C. Marin, Marisa Dreher, Ruchi Parekh, Ildiko Stark, Nils Eckstein, Aljoscha Nern, Tansy Yang, Yoshinori Aso, Gerald M. Rubin, Li, Feng [0000-0002-6658-9175], Lindsey, Jack W [0000-0003-0930-7327], Marin, Elizabeth C [0000-0001-6333-0072], Otto, Nils [0000-0001-9713-4088], Dreher, Marisa [0000-0002-0041-9229], Dempsey, Georgia [0000-0002-1854-8336], Bates, Alexander S [0000-0002-1195-0445], Pleijzier, Markus William [0000-0002-7297-4547], Schlegel, Philipp [0000-0002-5633-1314], Nern, Aljoscha [0000-0002-3822-489X], Takemura, Shin-Ya [0000-0003-2400-6426], Yang, Tansy [0000-0003-1131-0410], Francis, Audrey [0000-0003-1974-7174], Parekh, Ruchi [0000-0002-8060-2807], Costa, Marta [0000-0001-5948-3092], Scheffer, Louis K [0000-0002-3289-6564], Aso, Yoshinori [0000-0002-2939-1688], Jefferis, Gregory Sxe [0000-0002-0587-9355], Litwin-Kumar, Ashok [0000-0003-2422-6576], Waddell, Scott [0000-0003-4503-6229], Rubin, Gerald M [0000-0001-8762-8703], and Apollo - University of Cambridge Repository
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QH301-705.5 ,Computer science ,Science ,Sensory system ,neuronal circuits ,General Biochemistry, Genetics and Molecular Biology ,memory ,03 medical and health sciences ,0302 clinical medicine ,Stimulus modality ,Connectome ,Animals ,Experimental work ,Biology (General) ,Mushroom Bodies ,030304 developmental biology ,Brain Mapping ,0303 health sciences ,learning ,D. melanogaster ,General Immunology and Microbiology ,behavior ,General Neuroscience ,General Medicine ,Drosophila melanogaster ,Neuronal circuits ,Mushroom bodies ,Medicine ,Activity regulation ,dopamine ,Neuroscience ,030217 neurology & neurosurgery ,Function (biology) ,Research Article - Abstract
Making inferences about the computations performed by neuronal circuits from synapse-level connectivity maps is an emerging opportunity in neuroscience. The mushroom body (MB) is well positioned for developing and testing such an approach due to its conserved neuronal architecture, recently completed dense connectome, and extensive prior experimental studies of its roles in learning, memory, and activity regulation. Here, we identify new components of the MB circuit inDrosophila, including extensive visual input and MB output neurons (MBONs) with direct connections to descending neurons. We find unexpected structure in sensory inputs, in the transfer of information about different sensory modalities to MBONs, and in the modulation of that transfer by dopaminergic neurons (DANs). We provide insights into the circuitry used to integrate MB outputs, connectivity between the MB and the central complex and inputs to DANs, including feedback from MBONs. Our results provide a foundation for further theoretical and experimental work.
- Published
- 2020
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