Search

The accurate measurement of the 3D dose distribution of carbon-ion beams is essential for safe carbon-ion therapy. Although ionization chambers scanned in a water tank or air are conventionally used for this purpose, these measurement methods are time-consuming. We thus developed a rapid 3D dose-measurement tool that employs a silver-activated zinc sulfide (ZnS) scintillator with lower linear energy transfer (LET) dependence than gadolinium-based (Gd) scintillators; this tool enables the measurement of carbon-ion beams with small corrections. A ZnS scintillator sheet was placed vertical to the beam axis and installed in a shaded box. Scintillation images produced by incident carbon-ions were reflected with a mirror and captured with a charge-coupled device (CCD) camera. A 290 MeV/nucleon mono-energetic beam and spread-out Bragg peak (SOBP) carbon-ion passive beams were delivered at the Gunma University Heavy Ion Medical Center. A water tank was installed above the scintillator with the water level remotely adjusted to the measurement depth. Images were recorded at various water depths and stacked in the depth direction to create 3D scintillation images. Depth and lateral profiles were analyzed from the images. The ZnS-scintillator-measured depth profile agreed with the depth dose measured using an ionization chamber, outperforming the conventional Gd-based scintillator. Measurements were realized with smaller corrections for a carbon-ion beam with a higher LET than a proton. Lateral profiles at the entrance and the Bragg peak depths could be measured with this tool. The proposed method would make it possible to rapidly perform 3D dose-distribution measurements of carbon-ion beams with smaller quenching corrections.

Radiochromic films are useful as dosimeters in high-precision radiotherapy owing to their high spatial resolution. However, when a particle beam is measured using a radiochromic film, the dose cannot be estimated accurately because the film darkness varies with variations in linear energy transfer (LET). This paper proposes a novel method for estimating the LET and the dose based on the film darkness. In this method, after a high-LET particle beam, such as a carbon-ion beam, was incident on the film, the film was digitized and its net optical density was determined. Further, the non-linearity of the film response curve between the dose and the darkness, depending on LET, was used. Then, calibration curves were created using 290 MeV u−1 mono energetic carbon-ion beams. We used LETs of 20, 50, 100, and 150 keV µm−1 and a physical dose of 2–14 Gy. The calibration curves were approximated for each LET using a quadratic function. The correlations between the coefficients of the quadratic function and the LET were also obtained. To verify the proposed method, the films were irradiated under 12 different conditions corresponding to various depths and doses. Four depths of −2, −5, −10, and −20 mm with respect to the Bragg peak, and three different preset values were used for the film measurements. The films were analyzed in four groups, where each group comprised films irradiated at the same depth. The LETs obtained from the film analysis, ordered from the upstream of the beam, were 20, 41, 56, and 97 keV µm−1, and the doses for the lowest preset value were 3.95, 4.07, 4.03, and 3.99 Gy for the four groups. The LETs obtained from the film analysis increased toward the Bragg peak, and the doses measured in the ionization chamber were almost equal to 4 Gy.

In a conventional carbon-ion radiotherapy facility, a carbon-ion beam is typically accelerated up to an optimum energy, slowly extracted from a synchrotron ring by a resonant slow extraction method, and ultimately delivered to a patient through a beam-delivery system. At Japan’s Gunma University, a method employing slow-beam extraction along with beam-acceleration has been adopted. This method slightly alters the extracted-beam’s energy owing to the acceleration component of the process, which subsequently results in a residual-range variation of approximately 2 mm in water-equivalent length. However, this range variation does not disturb a distal dose distribution with broad-beam methods such as the single beam-wobbling method. With the pencil-beam 3D scanning method, however, such a range variation disturbs a distal dose distribution because the variation is comparable to slice thickness. Therefore, for pencil-beam 3D scanning, an energy compensation method for a slow extracted beam is proposed in this paper. This method can compensate for the aforementioned energy variances by controlling net energy losses through a rotatable energy absorber set fixed between the synchrotron exit channel and the isocenter. Experimental results demonstrate that beam energies can be maintained constant, as originally hypothesized. Moreover, energy-absorber positions were found to be significantly enhanced by optimizing beam optics for reducing beam-size growth by implementation of the multiple-scattering effect option.

Precise measurement of the dose distribution of a carbon-ion pencil beam is essential for the safe delivery of treatment in scanned carbon-ion therapy. We developed an easy-to-use and quick dose-measurement tool that employs a silver-activated zinc-sulfide (ZnS) scintillator, which shows a smaller linear energy transfer (LET) dependency than conventional Gd-based scintillator, to measure the dose distribution of a carbon-ion pencil beam with high spatial resolution and small corrections. A ZnS scintillator sheet was set up perpendicular to the beam axis, and scintillation images were recorded using a charge-coupled device camera. We used 290-MeV/nucleon monoenergetic carbon-ion pencil beams at the Gunma University Heavy Ion Medical Center. The thickness of the water tank placed above the scintillator was remotely controlled to adjust the measurement depth. Images were acquired at different water depths, and the depth and lateral profiles were determined from the images. The results were compared with those of conventional Gd-based scintillator. The depth–light intensity profile of the ZnS scintillator matched the depth dose measured using an ionization chamber, which was better than that of a Gd-based scintillator. This result is advantageous for measurements using a carbon-ion pencil beam, which consists of primary carbon ions with a much higher LET than a proton, with smaller corrections. The ZnS scintillator showed good output characteristics, dose linearity (R2 > 0.99), and output reproducibility (deviations below 2%) and good agreement with the lateral-dose profiles measured using a diode down to ~1% of the central dose. The proposed tool can measure lateral profiles at the depth of the Bragg peak and tail in addition to the entrance. Our tool was used to quickly measure the dose distribution of carbon-ion pencil beam with high-spatial resolution and small corrections.

We have succeeded to compress the energy spread of a laser-produced proton beam to 1.6% at FWHM by an RF electric field synchronous to the pulse laser. Protons generated by this laser originally had a continuous energy spectrum with no peaks. Radial focusing and defocusing effects caused by the transverse component of the RF field were also observed. Concerning these effects, we simulated the energy spectra from the calculated value of the electric field by POISSON; the simulation could almost reproduce the experimental results. By applying this beam as an injection beam of a synchrotron, a compact acceleration system for particle cancer therapy is expected to be realized.

A closed orbit is corrected for single-turn injection to perform laser cooling experiments of 40 keV 24 Mg + beam at the small laser-equipped storage ring (S-LSR). Closed orbit distortion (COD) corrections have been carried out using a downhill simplex method, and CODs of less than ± 0.5 mm have been achieved throughout the whole circumference. The injection orbit and the CODs are optimized to pass through the two aperture holes in the alignment targets located in the laser cooling section with an algorithm to maximize beam lifetime. The CODs at the aperture holes are reduced to be less than ± 0.2 mm , assuring an overlap between the laser and the 24 Mg + ion beam.

A short-pulse (~210 fs) high-power (~1 TW) laser was focused on a tape target 3 and 5 µm in thickness to a size of 11×15 µm2 with an intensity of 3×1017 W/cm2. Protons produced by this laser with an energy spread of 100% were found to be improved to create peaks in the energy distribution with a spread of ~7% by the application of the RF electric field with an amplitude of ±40 kV synchronous to the pulsed laser. This scheme combines the conventional RF acceleration technique with laser-produced protons for the first time. It is possible to be operated up to 10 Hz, and is found to have good reproducibility for every laser shot with the capability of adjusting the peak positions by control of the relative phase between the pulsed laser and the RF electric field.

In order to widely spread out particle beams utilized in cancer therapy, laser-produced ions are developed as the injection beam for an ion synchrotron dedicated for cancer therapy. Such a laser ion source is expected to contribute largely to the realization of compactness of the size and low cost of the cancer therapy accelerator. The energy spectrum of the laser-produced ions, however, has no peak, but their intensities decrease exponentially according to the increase of the energy. For the purpose of modifying such a situation, we have proposed a scheme to rotate the beam in the longitudinal phase space with the use of the RF electric field, which is phase-adjusted with the pulse laser. We aim for a reduction of the energy spread of ± 5% selected by an energy analyzer and slits to ±1% by such phase rotation. For this purpose, a quarter wavelength resonator with two gaps with the same resonant frequency as the source laser has already been fabricated, together with its RF power source. The above phase rotation system and its recent experimental realization are presented.

We report the first observation of indirect resonantly enhanced transverse laser cooling of a bunched, stored ion beam of 40 keV $^{24}\mathrm{Mg}^{+}$. The longitudinal velocity distribution and the horizontal beam size of the laser-cooled $^{24}\mathrm{Mg}^{+}$ ion beam with 280 nm laser light were simultaneously observed by the use of standard fluorescence-based techniques. Keeping the operation point at (2.068, 1.105), the synchrotron tune (${\ensuremath{\nu}}_{s}$) was changed from 0.0376 to 0.1299. A strong decrease in the cooled horizontal beam size and a corresponding increase in the equilibrium cooled momentum spread were observed at the expected synchrobetatron resonance coupling condition of ${\ensuremath{\nu}}_{s}=0.068$, which is the first observation of a resonantly induced coupling for enhanced indirect transverse laser cooling of an ion beam, and is an important step towards creating a crystalline ground state of the beam.

The dynamics of a MeV laser-produced proton beam affected by a radio frequency (rf) electric field has been studied. The proton beam was emitted normal to the rear surface of a thin polyimide target irradiated with an ultrashort pulsed laser with a power density of $4\ifmmode\times\else\texttimes\fi{}{10}^{18}\text{ }\text{ }\mathrm{W}/{\mathrm{cm}}^{2}$. The energy spread was compressed to less than 11% at the full width at half maximum (FWHM) by an rf field. Focusing and defocusing effects of the transverse direction were also observed. These effects were analyzed and reproduced by Monte Carlo simulations. The simulation results show that the transversely focused protons had a broad continuous spectrum, while the peaks in the proton spectrum were defocused. Based on this new information, we propose that elimination of the continuous energy component of laser-produced protons is possible by utilizing a focal length difference between the continuous spectral protons and the protons included in the spectral peak.

At S-LSR, abrupt reduction of momentum spread of 7 MeV proton beam to ~2 times 10-6 at proton number of -2000 has been observed, which indicates phase transition to 1 dimensional ordered state. Attained proton temperatures after transition are 26 mueV and 1 meV for longitudinal and transverse directions, respectively, which compared with the corresponding values of 20 mueV and 34 meV for electron beam, indicates the magnetization of electron. Laser cooling of 24Mg+ has also been started and momentum spread of ~108 ions is reduced to 2 times 10-4, saturated with the momentum transfer from transverse degree of freedom by intra-beam scattering.

The ordering of protons has been observed at a new storage ring, S-LSR, at Kyoto University. Abrupt jumps in the momentum spread and the Schottky noise power were observed for protons for the first time at a particle number of $\ensuremath{\sim}2000$, upon applying electron cooling with electron currents of 25, 50, and 100 mA. The transition temperature was 0.17 and 1 meV in the longitudinal and transverse directions, respectively. The transverse temperature of the proton beam was much below that of electrons at the transition, which played an essential role in the ordering of protons.

A compact ion cooler ring, S‐LSR is under construction in Kyoto University. One of the subjects of S‐LSR is a realization of the crystalline beams using the electron beam and the laser cooling. The ring is designed to be satisfied several required conditions for the beam ordering, such as a small betatron phase advance, a small magnetic error and a precise magnet alignment. The design phase advance per a period is less than 127 degree. The calculated closed orbit distortion and the stopband is less than 1 mm and 0.001 without correction, respectively.

A single particle dynamics in beam bending elements including electrostatic fields is formulated. A general form of scalar potentials of electrostatic deflectors is obtained from solutions of the Maxwell equation having axial symmetry. Equations of motion of a charged particle in various types of the electrostatic deflectors are derived based on Hamiltonian formalism. The equation of motion in dispersion suppressors, which are a combination of the electrostatic deflectors and dipole magnets, are also formulated and generalized. Application of one of the dispersion suppressors to an existing heavy ion storage ring S-LSR provides the better condition for generation of a multidimensional crystalline beam. It is shown that this condition is achievable by real fabricated devices composed of a dipole magnet and an electrostatic deflector equipped with intermediate electrodes. The effectiveness of this dispersion suppressor for the real operation is shown by a particle tracking including the nonlinear field component.

The efficiency of indirect transverse laser cooling with synchro-betatron resonance coupling has been improved with the reduction in beam intensity by scraping the tail part of the beam. In order to measure the beam size at a low beam intensity, a new scheme to measure the beam profile by observation of the survival ratio with changing the scraper position has been established. With 104 particles, the transverse cooling time was reduced to 1.2 s, and the cooled horizontal and vertical beam sizes were 0.19 and 0.61 mm, corresponding to temperatures of 20 and 29 K, respectively, which is largely improved compared with that in our previous experiment [Nakao et al.: Phys. Rev. ST Accel. Beam 15 (2012) 110102].

A laser-cooling experiment of a 40 keV 24Mg+ beam was carried out in the small laser-equipped storage ring (S-LSR). A laser co-propagating with the beam and an induction accelerator were utilized in the experiment. The lowest longitudinal temperature achieved in the present experiment was 3.6 K for 3?104 ions stored in the ring. It was found that the number of stored ions is related to the temperature at the final equilibrium state of the laser cooling. This relation shows that the longitudinal temperature of the laser-cooled beam linearly couples with the transverse one through intra-beam scattering.

Laser ion production has been studied for downsizing of the accelerator dedicated for cancer therapy. For optimization of various parameters such as pre-pulse condition, target position, laser spot size on the target, laser pulse width and so on, time of flight (TOF) measurement utilizing the detected signal by a plastic scintillation counter played an essential role for real time measurement. Protons up to ~900 keV and ~600 keV are produced from the thin foil targets of Ti 3 μm and 5 μm in thickness, respectively. Modification of the energy distribution of the laser-produced ions with Maxwell distribution by utilizing an RF electric field synchronized to the pulse laser, which is the rotation of the ion beam in the longitudinal phase space (Phase Rotation), has been demonstrated for the first time. By using the Ti Sapphire laser of the wave length and pulse duration of 800 nm and a few hundreds fs, respectively, intensity increase of factor 3 in a certain energy bins is attained creating energy peaks with the energy spread about 7 %, which is found to be reproduced with good probability.