1. Wireless, battery-free and wearable device for electrically controlled drug delivery: sodium salicylate released from bilayer polypyrrole by near-field communication on smartphone
- Author
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Zhaoyang Liu, Xin Li, Yanli Lu, Qingjun Liu, Zetao Chen, Jinglong Liu, Gang Xu, Lihang Zhu, and Chen Cheng
- Subjects
Paper ,Drug ,Battery (electricity) ,Materials science ,Polymers ,Sodium Salicylate ,media_common.quotation_subject ,Biomedical Engineering ,Wearable computer ,02 engineering and technology ,Polypyrrole ,01 natural sciences ,Near field communication ,Wearable Electronic Devices ,chemistry.chemical_compound ,Drug Delivery Systems ,Electricity ,Pyrroles ,Electrodes ,Molecular Biology ,media_common ,Transdermal ,010401 analytical chemistry ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,ComputingMethodologies_PATTERNRECOGNITION ,chemistry ,visual_art ,Drug delivery ,Electronic component ,visual_art.visual_art_medium ,Smartphone ,0210 nano-technology ,Wireless Technology ,Biomedical engineering - Abstract
Compared with traditional drug delivery methods, transdermal drug delivery has many advantages in avoiding the side effects in gastrointestinal tract, reducing the fluctuations in drug concentration, and improving patients' compliance. Among them, electrically controlled drug delivery is a promising solution. This work presents a wireless, battery-free and wearable device with electrically controlled drug delivery capability. The electronic component of the device is a flexible circuit board with a temperature sensor and a near-field communication module. With the help of smartphone, the device could wirelessly obtain energy and implement data transmission. The drug delivery component is a paper-based electrode modified with polypyrrole, in which non-steroidal anti-inflammatory drug sodium salicylate was encapsulated. The applied potential for electrically controlled drug delivery was more negative than -0.6 V. The drug release dose and release rates could be controlled by applying potentials with different amplitudes and durations through this device. It provided a minimalized wearable transdermal drug delivery platform for monitoring diseases such as gout. This wearable device shows promising potential in develop closed-loop drug delivery and monitoring systems for the treatment of various diseases.
- Published
- 2020