1. Acute Akinesia, an unusual complication in Parkinson's Disease: a case report.
- Author
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Simonetto M, Ferigo L, Zanet L, Capus L, Antonutti L, Zorzon M, and Pizzolato G
- Subjects
- Acute Disease, Aged, Antiparkinson Agents metabolism, Apomorphine administration & dosage, Basal Ganglia Diseases diagnosis, Basal Ganglia Diseases drug therapy, Creatine Kinase blood, Disease Progression, Dopamine Agonists administration & dosage, Fever chemically induced, Fever metabolism, Fever physiopathology, Humans, Male, Ondansetron administration & dosage, Respiratory Insufficiency, Serotonin Antagonists administration & dosage, Syndrome, Treatment Outcome, Antiparkinson Agents adverse effects, Basal Ganglia Diseases physiopathology, Drug Resistance, Parkinson Disease complications
- Abstract
Acute akinesia (AA) is a rare but serious complication of Parkinson's Disease (PD) 0,3% of all patients with PD). It can be related to infectious condition, surgery, or treatment changes. AA can completely recover or result in some motor deficits, and, in the most severe forms, it may lead to untreatable complications and death. Here we report the case of a 67-year-old man with PD who rapidly developed a severe akinetic state with rise of temperature (39 degrees C) and creatine phosphokinase concentration (up to 5000 mg/dL). After excluding infection diseases and other pathologies, we suspected AA and added apomorphine 50mg/die s.c. and ondansetron 8 mg i.v. The patient responded to treatment and ameliorated in few weeks.
- Published
- 2008
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