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Tumor of the follicular infundibulum is a rare, benign lesion of the skin; the very few cases presented in the literature had a clinical diagnosis of BCC with a histological analysis indicating tumor of the follicular infundibulum. Basal cell carcinoma is the most frequent eyelid malignancy, about 90%-95% of all eyelid malignant tumors. Differential diagnosis for tumor of the follicular infundibulum can be made based on clinical appearance with basal cell carcinoma, nevi, actinic keratosis, trichoepithelioma, seborrheic keratosis, warts. Benign tumors like tumor of the follicular infundibulum can be safely excised with a narrow margin making their clinical diagnosis important in order to avoid extensive surgery. Histopathological characteristics of the tumor of the follicular infundibulum are unique and provide an accurate diagnosis.

Rationale: Eyelids are very susceptible area for non-melanoma skin cancers; among that, basal cell carcinoma has the highest incidence (almost 90% of malignant eyelid tumors) and 50-60% of eyelid basal cell carcinomas appear on inferior eyelid. Objective: To analyze clinical features of inferior eyelid basal cell carcinoma and to determine the efficacy of surgical treatment with frozen sectioncontrolled margins and methods of primary reconstruction of defects. Methods: A review of medical records of cases with primary inferior eyelid basal cell carcinoma treated by surgical excision with urgent histopathology controlled margins by FS technique, doubled by paraffin examination from October 2011 to October 2014. After histopathology confirmation of tumor free margins, proper inferior eyelid reconstruction was performed. Results: The review resulted in 36 patients with 36 lesions analyzed by clinical, histopatological and therapeuticalaspectswith a mean follow-up of 20 months. All lesions were primary BCC affecting inferior eyelid. There were no recurrence in the follow-up period. Inferior eyelid reconstruction techniques were direct closure for small defects and complex techniques for defects more than one third of eyelid length. Discussion: Appropriate eyelid examination is mandatory in any routine ophthalmic check-up. Clinical signs suggestive of BCC should be familiar to ophthalmologist in order to have an early diagnosis and treatment for these tumors. Surgical treatment with FS controlled excision followed by eyelid reconstruction is an efficient treatment for inferior eyelid BCC. Abbreviations: basal cell carcinoma (BCC); frozen section (FS);Mohs micrographic surgery (MMS).