1. Bartter's syndrome with gouty arthritis.
- Author
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Ogawa T, Fujise Y, Shibata S, Abiru M, Takigami Y, Miura T, Kikuchi K, Fukazawa Y, and Iimura O
- Subjects
- Bartter Syndrome metabolism, Female, Humans, Kidney Tubules physiopathology, Middle Aged, Renin-Angiotensin System, Uremia etiology, Uric Acid blood, Uric Acid metabolism, Arthritis, Gouty etiology, Bartter Syndrome complications
- Abstract
A 45-year-old woman with Bartter's syndrome complicated with gouty arthritis is reported. Bartter's syndrome was diagnosed from hypokalemia, metabolic alkalosis, high plasma renin activity, normal blood pressure and attenuated pressor response to exogenous angiotensin II infusion. Serum uric acid was 11.8 mg/dl, the renal clearance of uric acid was low (3.0 ml/min) and fractional excretion of uric acid (FEUA) was 7.0%, being the lower limit of the normal range. Fractional excretion of phosphate was low (5.3%) and fractional free water clearance per fractional distal sodium delivery was 0.51. The mechanism of hyperuricemia in this case is discussed.
- Published
- 1992
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