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Your search keyword '"Md Shaki Mostaid"' showing total 4 results
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4 results on '"Md Shaki Mostaid"'

1. Polymorphisms of the interleukin‐6 (IL‐6) gene contribute to cervical cancer susceptibility in Bangladeshi women: A case‐control study

Author

Monishita Shaswati, Fihima Hossain Oeishy, Sadia Biswas Mumu, Md Zahidul Islam Zahid, Murad Hossain, Md Aminul Haque, Hasan Mahmud Reza, and Md Shaki Mostaid

Subjects
Bangladesh, cervical cancer, interleukin‐6, polymorphism, rs1800795, rs1800797, Medicine
Abstract

Abstract Background and Aims Cervical cancer is characterized by abnormal cell growth in the lining of cervix and it is the second major cause of cancer‐related deaths among females in Bangladesh. Interleukin‐6 (IL‐6) is a multifunctional cytokine that has been heavily linked with cervical cancer. Our aim was to investigate the association of two promoter single‐nucleotide polymorphisms (SNPs) of IL‐6 (rs1800795 and rs1800797) with the susceptibility of cervical cancer in Bangladeshi women. Methods DNA was extracted from venous blood samples from cervical cancer patients (n = 126) and healthy controls (n = 120). Polymerase chain reaction‐restriction fragment length polymorphism was used for genotyping of the selected SNPs. Logistic regression was performed to calculate the odds ratio (OR) with 95% confidence interval (CI) and p values. Results We found a significant association between rs1800795 and rs1800797 polymorphisms and cervical cancer. For, rs1800795 (G > C) the GC heterozygous genotype (OR = 2.80, 95% CI = 1.55–5.07, p = 0.0007) and CC mutant homozygous genotype (OR = 3.5, 95% CI = 1.29–9.51, p = 0.014) conferred an increased risk of cervical cancer. In case of rs1800797 (G > A) polymorphism, the AG heterozygous genotype (OR = 6.94, 95% CI = 3.76–12.81, p

Published
2023
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2. TP53 genetic polymorphisms and susceptibility to cervical cancer in Bangladeshi women: a case-control study

Author

Mohd Nazmul Hasan, Apu, A Z M, Rashed, Tafsir, Bashar, Md Morshadur, Rahman, and Md Shaki, Mostaid

Subjects
Adult, Bangladesh, Genotype, Uterine Cervical Neoplasms, Middle Aged, Genes, p53, Polymorphism, Single Nucleotide, Gene Frequency, Risk Factors, Case-Control Studies, Ethnicity, Humans, Female, Genetic Predisposition to Disease, Disease Susceptibility, Tumor Suppressor Protein p53, Codon, Alleles
Abstract

Pharmacogenetic study of TP53 gene polymorphisms has not been conducted extensively in cervical cancer. The aim of this study was to assesses the TP53 codon 72 and codon 47 polymorphisms and their relation to cervical cancer risk in Bangladeshi women. 134 cervical cancer patients and 102 age matched healthy controls were included from two institutions in Bangladesh. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used for genotyping two TP53 single nucleotide polymorphisms (codon 72 and codon 47) in patients and controls. The results indicate that the TP53 Arg/Pro heterozygosity (adjusted OR 2.32, 95% CI 1.28-4.34, p = 0.01), Pro/Pro mutant homozygosity (adjusted OR 4.15, 95% CI 1.75-9.86, p = 0.001), along with the combined genotype (Arg/Pro + Pro/Pro) (adjusted OR 2.83, 95% CI 1.61-4.97, p 0.001) significantly increases the risk of cervical cancer. Moreover, the cervical cancer patients with a first-degree relative cancer patient possesses 4.45 folds more risk (p = 0.019) of carrying a proline allele in codon 72 of the TP53 gene compared to those patients who do not have any first-degree relative with cancer. Finally, polymorphism in the codon 47 of the TP53 gene did not significantly increase the risk of cervical cancer in Bangladeshi women. To conclude, this is the first study to identify that polymorphism in the TP53 codon 72 significantly increases the risk of cervical cancer in a female population in Bangladesh.

Published
2020

3. Elevated serum expression of p53 and association of TP53 codon 72 polymorphisms with risk of cervical cancer in Bangladeshi women

Author

Md Shaki Mostaid, Sadia Biswas Mumu, Md Aminul Haque, Shahana Sharmin, Mohd Raeed Jamiruddin, Ghazi Muhammad Sayedur Rahman, and Hasan Mahmud Reza

Subjects
Serum Proteins, Heredity, Epidemiology, Biopsy, Single Nucleotide Polymorphisms, Protein Expression, Uterine Cervical Neoplasms, Cervical Cancer, Biochemistry, Odds Ratio, Medicine and Health Sciences, Amino Acids, Bangladesh, Multidisciplinary, Organic Compounds, Cancer Risk Factors, Middle Aged, Genetic Mapping, Chemistry, Oncology, Physical Sciences, Medicine, Female, Research Article, Adult, Risk, Heterozygote, Genotype, Proline, Science, Quantitative Trait Loci, Variant Genotypes, Research and Analysis Methods, Polymorphism, Single Nucleotide, Risk Assessment, Malignant Tumors, Gene Expression and Vector Techniques, Genetics, Humans, Genetic Predisposition to Disease, Codon, Molecular Biology Techniques, Molecular Biology, Molecular Biology Assays and Analysis Techniques, Organic Chemistry, Chemical Compounds, Cancers and Neoplasms, Biology and Life Sciences, Proteins, Cyclic Amino Acids, Genes, p53, Case-Control Studies, Medical Risk Factors, Linear Models, Tumor Suppressor Protein p53, Gynecological Tumors
Abstract

Differential expression of p53 has been reported in cervical cancer, primarily in tumor tissue biopsies. In this study, we examined the association of TP53 codon 47 and codon 72 polymorphisms and serum level expression of p53 in cervical cancer patients (n = 129) and healthy controls (n = 122). We found elevated levels of serum p53 protein levels in cervical cancer patients (p = 0.0442) compared to healthy controls. Moreover, we found higher levels of serum p53 in patients with grade-III tumor (p = 0.001) compared to healthy controls. Examination of SNPs showed TP53 Arg/Pro heterozygosity (adjusted OR = 2.126, 95% CI = 1.181–3.827, p = 0.012), Pro/Pro mutant homozygosity (adjusted OR = 3.564, 95% CI = 1.647–7.713, p = 0.001), along with the combined genotype (Arg/Pro+Pro/Pro) (adjusted OR 2.542, 95% CI = 1.517–4.260, p

Published
2021
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4. Lung cancer risk in relation to TP53 codon 47 and codon 72 polymorphism in Bangladeshi population

Author

Maizbha Uddin Ahmed, Mohammad Safiqul Islam, Muhammad Shahdaat Bin Sayeed, Abul Hasnat, and Md. Shaki Mostaid

Subjects
Adult, Male, medicine.medical_specialty, Lung Neoplasms, Adolescent, Genotype, Population, Bioinformatics, Gastroenterology, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Young Adult, Asian People, Risk Factors, Internal medicine, Medicine, SNP, Humans, Genetic Predisposition to Disease, Young adult, education, Lung cancer, Codon, Aged, Aged, 80 and over, education.field_of_study, Bangladesh, business.industry, Smoking, Case-control study, General Medicine, Odds ratio, Middle Aged, medicine.disease, Confidence interval, Case-Control Studies, Female, Tumor Suppressor Protein p53, business, Polymorphism, Restriction Fragment Length
Abstract

The objective of this study was to determine whether p53 codon 47 and codon 72 polymorphisms are associated with increased risk of lung cancer in Bangladeshi population. We carried out a case-control study and examined the genotype distribution Pro47Ser and Arg72Pro single-nucleotide polymorphisms along with tobacco smoking in the predisposition of lung cancer by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) approach. The study included 106 lung cancer patients and 116 control subjects from Bangladesh. Lung cancer risk was estimated as odds ratio (OR) and 95 % confidence interval (CI) using conditional logistic regression models adjusting for age, sex, and smoking. No significant association was found between Pro47Ser SNP and lung cancer. The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in lung cancer were 25.5, 37.7, and 36.8 %, respectively; frequencies in the controls were 53.4, 30.2, and 16.4 %, respectively (p

Published
2014

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