1. Synergistic effect of Cydonia oblonga and its extracted silver nanoparticles for improving antioxidant and antibacterial activity of 3D printed alginate-based hydrogel as wound dressing.
- Author
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Ashtariyan A, Mollania H, Annabestani N, Mollania N, Malayjerdi F, Dolatabadi M, Ghomi ER, Khoshsima A, and Neisiany RE
- Subjects
- Animals, Wound Healing drug effects, Microbial Sensitivity Tests, Metal Nanoparticles chemistry, Silver chemistry, Silver pharmacology, Alginates chemistry, Alginates pharmacology, Antioxidants pharmacology, Antioxidants chemistry, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents chemistry, Hydrogels chemistry, Hydrogels pharmacology, Plant Extracts chemistry, Plant Extracts pharmacology, Bandages, Printing, Three-Dimensional
- Abstract
The current research studies the synergistic effect of Cydonia oblonga and its extracted nano bio‑silver as a natural and eco-friendly agent for the improvement of three-dimensional (3D)-printed alginate wound dressings. Therefore, Cydonia oblonga extract was first prepared and silver nanoparticles were extracted from it through a green and simple method. The Cydonia oblonga and its extracted bio-based nanoparticles were then added to 3D printing alginate-based ink. Subsequently, a 3D structural extrusion printer was employed to create the porous hydrogel-based wound dressings. The morphological investigation demonstrated that using the extraction method the bio-based silver nanoparticles were successfully prepared, having an average size of 17.95 ± 4.50 nm. The Cydonia oblonga extract showed comparable antioxidant activity to the commercial antioxidant and an excellent total phenol content. In addition, the results showed the combination of Cydonia oblonga extracts/silver nanoparticles significantly improved the antibacterial performance of alginate-based bioinks. In vivo, and in vitro studies confirmed their biocompatibility and significant efficacy in the treatment of burn wounds., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Published
- 2024
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