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Background and aim: The balance of endotracheal tube (ETT) cuff pressure is necessary to prevent complications and to perform a proper therapeutic treatment on the patient. The aim of this study was to determine ETT cuff pressure in comparison with the standard level in intensive care unit (ICU) intubated patients. Methods: In this descriptive-analytical study conducted in Kashani Hospital in Shahrekord, southwestern Iran in 2014-2015, the 200 ICU patients intubated for any reason participated. All measurements of ETT cuff pressure were conducted by researchers using a manometer, and were expressed as mmHg. In this study, a checklist was used to record the data and then the data were analyzed by the SPSS version 16 using descriptive statistics, ANOVA, t-test, and chi-square test. Results: Mean cuff pressure was 30.97 +/- 16.53 mmHg. The cutoff point of cuff pressure with 95% confidence interval was obtained 28.66-33.28 mmHg. Since this range overlaps the standard range (30-25 mmHg) for cuff pressure, it can be said, with 95% confidence, that the cuff pressure in the target population is in concordance with the standard range. Gender, height, the mean number of intubation days, level of consciousness and decrease of oxygen saturation, lung pharyngeal reflex, and work experience of the cuff filler were not significantly associated with cuff pressure (P > 0.05), but there was a significant association between weight and cuff pressure (P = 0.01). Conclusion: Although in this study, the cuff pressure in a number of patients was outside the standard range, the cuff pressure was generally in concordance with the standard range.