1. Effects of Baicalin on Airway Remodeling in Asthmatic Mice.
- Author
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Jing Sun, LuLu Li, JinFeng Wu, BaoJun Liu, WeiYi Gong, YuBao Lv, QingLi Luo, XiaoHong Duan, and Jing Cheng Dong
- Subjects
DRUG therapy for asthma ,ANALYSIS of variance ,ANIMAL experimentation ,BIOPHYSICS ,CYTOKINES ,ENZYME-linked immunosorbent assay ,FLAVONOIDS ,IMMUNOHISTOCHEMISTRY ,RESEARCH methodology ,MICE ,MOLECULAR structure ,PLETHYSMOGRAPHY ,RESEARCH funding ,RESPIRATORY organ physiology ,STATISTICAL sampling ,T-test (Statistics) ,WESTERN immunoblotting ,PLANT extracts ,DATA analysis software ,DESCRIPTIVE statistics - Abstract
Airway remodeling is an important characteristic of asthma, linking inflammation with airway hyperresponsiveness. Baicalin, a major active component, was isolated from Radix Scutellariae. Many studies show that baicalin has anti-inflammatory, anti-bacterial, and anti-allergic effects. Here we investigate the influence of baicalin on asthmatic airway remodeling and the mechanism underlining the anti-remodeling effect in vivo. Asthmatic airway remodelingmice modelwas established by ovalbumin exposure. Seventy female BALB/cmicewere randomly assigned to seven experimental groups: blank, ovalbumin, hexadecadrol, control, and baicalin (25 mg/kg, 50 mg/kg, 100 mg/kg) groups. Pulmonary function was measured using a whole-body plethysmograph in conscious and unrestrained mice. The lung pathology was observed and measured. The production of cytokines in bronchoalveolar lavage fluid and serum was measured using enzyme-labeled immunosorbent assay kits, and the expression levels of transforming growth factor-β
1 and vascular endothelial growth factor were detected by immunohistochemistry. The protein expression levels of transforming growth factor-β1, vascular endothelial growth factor, extracellular signal-regulated kinase, and p21ras were measured usingWestern blot. The results show that ovalbumin exposure significantly increased the expression of interleukin-13 in BALF and serum, and transforming growth factor-β1 , vascular endothelial growth factor, extracellular signal-regulated kinase and p21ras expressions in the lungs. Baicalin attenuated the effects of ovalbumin significantly. It can be concluded that baicalin has significant anti-remodeling effect on ovalbumin-induced asthmatic airway remodeling mice model by decreasing expression of transforming growth factor-β1 , interleukin-13, and vascular endothelial growth factor and inhibiting the activation of the extracellular signal-regulated kinase pathway. [ABSTRACT FROM AUTHOR]- Published
- 2013
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