1. Characterization of a bacteriocin-like substance produced by a vaginal Lactobacillus salivarius strain.
- Author
-
Ocaña VS, Pesce De Ruiz Holgado AA, and Nader-Macías ME
- Subjects
- Bacteriocins pharmacology, Candida drug effects, Drug Resistance, Microbial, Enterococcus faecalis drug effects, Enterococcus faecium drug effects, Female, Humans, Kinetics, Lactobacillus growth & development, Lactobacillus isolation & purification, Microbial Sensitivity Tests, Neisseria gonorrhoeae drug effects, Bacteriocins biosynthesis, Lactobacillus metabolism, Vagina microbiology
- Abstract
A novel bacteriocin-like substance produced by vaginal Lactobacillus salivarius subsp. salivarius CRL 1328 with activity against Enterococcus faecalis, Enterococcus faecium, and Neisseria gonorrhoeae was characterized. The highest level of production of this heat-resistant peptide or protein occurred during the late exponential phase. Its mode of action was shown to be bactericidal. L. salivarius subsp. salivarius CRL 1328 could be used for the design of a probiotic to prevent urogenital infections.
- Published
- 1999
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