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Your search keyword '"Chudejova K"' showing total 5 results
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5 results on '"Chudejova K"'

1. Emergence of Escherichia coli ST131 carrying carbapenemase genes, European Union/European Economic Area, August 2012 to May 2024.

Author

Kohlenberg A, Svartström O, Apfalter P, Hartl R, Bogaerts P, Huang TD, Chudejova K, Malisova L, Eisfeld J, Sandfort M, Hammerum AM, Roer L, Räisänen K, Dortet L, Bonnin RA, Tóth Á, Tóth K, Clarke C, Cormican M, Griškevičius A, Khonyongwa K, Meo M, Niedre-Otomere B, Vangravs R, Hendrickx AP, Notermans DW, Samuelsen Ø, Caniça M, Manageiro V, Müller V, Mäkitalo B, Kramar U, Pirs M, Palm D, Monnet DL, Alm E, and Linkevicius M

Subjects
Humans, Europe epidemiology, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use, Microbial Sensitivity Tests, Multilocus Sequence Typing, Escherichia coli Proteins genetics, beta-Lactamases genetics, Escherichia coli genetics, Escherichia coli isolation & purification, Escherichia coli Infections epidemiology, Escherichia coli Infections microbiology, European Union, Bacterial Proteins genetics
Abstract

Analysis of 594 isolates of Escherichia coli sequence type (ST)131 and its single locus variants carrying carbapenemase genes from 17 European Union/European Economic Area countries revealed acquisition of 18 carbapenemase variants, mainly in ST131 clades A and C. Most frequent were bla OXA-244 (n = 230) and bla OXA-48 (n = 224), detected in 14 and 12 countries, respectively. Isolates carrying bla OXA-244 have increased rapidly since 2021. The increasing detection of carbapenemase genes in the E. coli high-risk lineage ST131 is a public health concern.

Published
2024
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2. Evidence of an epidemic spread of KPC-producing Enterobacterales in Czech hospitals.

Author

Kraftova L, Finianos M, Studentova V, Chudejova K, Jakubu V, Zemlickova H, Papagiannitsis CC, Bitar I, and Hrabak J

Subjects
Anti-Bacterial Agents pharmacology, Bacterial Proteins genetics, Czech Republic epidemiology, Epidemics, Humans, Klebsiella Infections microbiology, Klebsiella pneumoniae metabolism, Bacterial Proteins metabolism, Drug Resistance, Bacterial, Hospitals statistics & numerical data, Klebsiella Infections epidemiology, Klebsiella pneumoniae isolation & purification, beta-Lactamases metabolism
Abstract

The aim of the present study is to describe the ongoing spread of the KPC-producing strains, which is evolving to an epidemic in Czech hospitals. During the period of 2018-2019, a total of 108 KPC-producing Enterobacterales were recovered from 20 hospitals. Analysis of long-read sequencing data revealed the presence of several types of bla KPC -carrying plasmids; 19 out of 25 bla KPC -carrying plasmids could be assigned to R (n = 12), N (n = 5), C (n = 1) and P6 (n = 1) incompatibility (Inc) groups. Five of the remaining bla KPC -carrying plasmids were multireplicon, while one plasmid couldn't be typed. Additionally, phylogenetic analysis confirmed the spread of bla KPC -carrying plasmids among different clones of diverse Enterobacterales species. Our findings demonstrated that the increased prevalence of KPC-producing isolates was due to plasmids spreading among different species. In some districts, the local dissemination of IncR and IncN plasmids was observed. Additionally, the ongoing evolution of bla KPC -carrying plasmids, through genetic rearrangements, favours the preservation and further dissemination of these mobile genetic elements. Therefore, the situation should be monitored, and immediate infection control should be implemented in hospitals reporting KPC-producing strains., (© 2021. The Author(s).)

Published
2021
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3. Emergence of sequence type 252 Enterobacter cloacae producing GES-5 carbapenemase in a Czech hospital.

Author

Chudejova K, Rotova V, Skalova A, Medvecky M, Adamkova V, Papagiannitsis CC, and Hrabak J

Subjects
Czech Republic, Enterobacter cloacae enzymology, Hospitals, Humans, Integrons genetics, Multilocus Sequence Typing, Bacterial Proteins genetics, Enterobacter cloacae genetics, Enterobacteriaceae Infections microbiology, beta-Lactamases genetics
Abstract

ST252 Enterobacter cloacae, producing GES-5 carbapenemase, was isolated in a Czech hospital. bla GES-5 was part of a novel class 1 integron, In1406, which also included a new allele of the aadA15 gene cassette. In1406 was located on a ColE2-like plasmid, pEcl-35771cz (6953bp)., (Copyright © 2017 Elsevier Inc. All rights reserved.)

Published
2018
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4. First description of the emergence of Enterobacter asburiae producing IMI-2 carbapenemase in the Czech Republic.

Author

Rotova V, Papagiannitsis CC, Chudejova K, Medvecky M, Skalova A, Adamkova V, and Hrabak J

Subjects
Anti-Bacterial Agents pharmacology, Bacterial Proteins genetics, Carbapenems pharmacology, Czech Republic, DNA, Bacterial, Drug Resistance, Bacterial drug effects, Drug Resistance, Bacterial genetics, Enterobacter drug effects, Enterobacter genetics, Enterobacteriaceae drug effects, Enterobacteriaceae enzymology, Enterobacteriaceae genetics, Humans, Microbial Sensitivity Tests, beta-Lactamases genetics, Bacterial Proteins metabolism, Enterobacter enzymology, beta-Lactamases metabolism
Published
2017
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5. Comparison of imipenem and meropenem antibiotics for the MALDI-TOF MS detection of carbapenemase activity.

Author

Rotova V, Papagiannitsis CC, Skalova A, Chudejova K, and Hrabak J

Subjects
Bacterial Proteins analysis, Bacteriological Techniques methods, Carbapenems pharmacology, Enterobacteriaceae drug effects, Enterobacteriaceae enzymology, Meropenem, Microbial Sensitivity Tests, Pseudomonas aeruginosa drug effects, Pseudomonas aeruginosa enzymology, beta-Lactamases analysis, Anti-Bacterial Agents pharmacology, Bacterial Proteins metabolism, Imipenem pharmacology, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization methods, Thienamycins pharmacokinetics, beta-Lactamases metabolism
Abstract

A comparison of carbapenem molecules for the detection of carbapenemase-producing bacteria by MALDI-TOF MS showed that imipenem exhibited higher sensitivity (97%) and specificity (100%) scores for Pseudomonas aeruginosa than meropenem. However, meropenem was more efficient (98% sensitivity and 100% specificity) against Enterobacteriaceae., (Copyright © 2017 Elsevier B.V. All rights reserved.)

Published
2017
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