1. Abdominal radiation causes bacterial translocation.
- Author
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Guzman-Stein G, Bonsack M, Liberty J, and Delaney JP
- Subjects
- Anesthesia, Animals, Bacteria radiation effects, Female, Intestinal Mucosa pathology, Intestines microbiology, Intestines pathology, Lymph Nodes microbiology, Mesentery, Rats, Rats, Inbred Strains, Time Factors, Abdomen radiation effects, Bacterial Physiological Phenomena
- Abstract
The purpose of this study was to determine if a single dose of radiation to the rat abdomen leads to bacterial translocation into the mesenteric lymph nodes (MLN). A second issue addressed was whether translocation correlates with anatomic damage to the mucosa. The radiated group (1100 cGy) which received anesthesia also was compared with a control group and a third group which received anesthesia alone but no abdominal radiation. Abdominal radiation lead to 100% positive cultures of MLN between 12 hr and 4 days postradiation. Bacterial translocation was almost nonexistent in the control and anesthesia group. Signs of inflammation and ulceration of the intestinal mucosa were not seen until Day 3 postradiation. Mucosal damage was maximal by Day 4. Bacterial translocation onto the MLN after a single dose of abdominal radiation was not apparently dependent on anatomical, histologic damage of the mucosa.
- Published
- 1989
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