1. Membrane Proteins as a Regulator for Antibiotic Persistence in Gram-Negative Bacteria.
- Author
-
Yee JX, Kim J, and Yeom J
- Subjects
- Humans, Membrane Proteins genetics, Membrane Proteins metabolism, Bacteria metabolism, Gram-Negative Bacteria genetics, Anti-Bacterial Agents metabolism, Bacterial Infections drug therapy
- Abstract
Antibiotic treatment failure threatens our ability to control bacterial infections that can cause chronic diseases. Persister bacteria are a subpopulation of physiological variants that becomes highly tolerant to antibiotics. Membrane proteins play crucial roles in all living organisms to regulate cellular physiology. Although a diverse membrane component involved in persistence can result in antibiotic treatment failure, the regulations of antibiotic persistence by membrane proteins has not been fully understood. In this review, we summarize the recent advances in our understanding with regards to membrane proteins in Gram-negative bacteria as a regulator for antibiotic persistence, highlighting various physiological mechanisms in bacteria., (© 2023. The Author(s), under exclusive licence to Microbiological Society of Korea.)
- Published
- 2023
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