1. [Monotherapy, empirical and targetted, with imipenem-cilastatin in sepsis of bacterial origin].
- Author
-
Fiorentino F, De Sena R, Manzillo E, Iadanza A, Conte M, Coppola MG, Galderisi P, Postiglione A, Arciello MT, and Covelli B
- Subjects
- Adolescent, Adult, Aged, Cilastatin, Imipenem Drug Combination, Drug Combinations therapeutic use, Drug Evaluation, Female, Humans, Male, Middle Aged, Anti-Bacterial Agents therapeutic use, Bacterial Infections drug therapy, Cilastatin therapeutic use, Fever of Unknown Origin drug therapy, Imipenem therapeutic use
- Abstract
The authors describe an open study in 22 patients with febrile conditions of unknown origin who were treated with imipenem-cilastatin while waiting for routine laboratory and culture tests. These were done immediately at the patients' entry into hospital, after which imipenem-cilastatin treatment was started immediately, and was subsequently confirmed by the isolates and culture tests. The drug was found to be active and to eradicate the responsible organism in all cases. In addition, it was found to be easy to handle and not to give rise to side-effects or changes in laboratory tests.
- Published
- 1989