1. Dynamics of cholera epidemics from Benin to Mauritania
- Author
-
Moore, S., Dongdem, A. Z., Opare, D., Cottavoz, P., Fookes, M., Sadji, A. Y., Dzotsi, E., Dogbe, M., Jeddi, F., Bidjada, B., Piarroux, M., Valentin, O. T., Glele, C. K., Rebaudet, S., Sow, A. G., Constantin de Magny, Guillaume, Koivogui, L., Dunoyer, J., Bellet, F., Garnotel, E., Thomson, N., Piarroux, R., Aix Marseille Université (AMU), University of Health and Allied Sciences [Ho] (UHAS), The Wellcome Trust Sanger Institute [Cambridge], Infections Parasitaires : Transmission, Physiopathologie et Thérapeutiques (IP-TPT), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Service de Santé des Armées, Departement de Parasitologie et Mycologie, Assistance Publique - Hôpitaux de Marseille (APHM), Department of Bacteriology, National Institute of Public Health - National Institute of Hygiene [Poland], Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur de Dakar, Réseau International des Instituts Pasteur (RIIP), Institut National de Santé Publique [Conakry, Guinée] (INSP), Ministère de la Santé [Conakry, Guinea], Hôpital d'Instruction des Armées Laveran, Service de Santé des Armées, Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), The investigations in Guinea, Ghana, Togo and Benin were supported by UNICEF WCARO and APHM –Hôpital de la Timone/Aix-Marseille University. WTSI authors were funded by Wellcome Trust grant number 098051. Certain cholera experts from UNICEF WCARO assisted in organizing the project (establishing meetings with key stakeholders) and data collection. JD and FB also contributed to manuscript redaction. The funding bodies at UNICEF WCARO, APHM and Wellcome Trust had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript., This study was possible thanks to extensive collaborations in each country. In Ghana, the authors would like to first extend our gratitude to our collaborators at the University of Health and Allied Sciences (Ho, Volta Region, Ghana), Bismarck Dinko, Gideon Kye-Duodu, Frank Nyonator, Fred Binka, and John Tampuori. We are extremely grateful to the staff of the Ghana Health Service, especially Badu Sarkodie, and the Disease Surveillance Officers who collected specimens and data on cholera cases. We thank Kweku Quansah from the Environmental Health and Sanitation Directorate for assistance with the study in Accra. We also thank Lawrence Henry Ofosu-Appiah and Lorreta Antwi from the National Public Health Reference Laboratory in Accra for technical assistance preparing and shipping the V. cholerae isolates. We also thank Ashon Ato, James Addo, Bernard Bright Davies-Teye, John Eleeza, Jonas Amanu, Rosemary Gbadzida, Joseph Kwami Degley, and Atsu Seake-Kwawu for assistance and discussions. We are also thankful to Anthony Karikari from Water Research Institute, Achimota for advice and discussions. We are very thankful to the UNICEF Accra office for their support: Samuel Amoako-Mensah, Kassim Yakubu Al-hassan, David Duncan, and Daniel Yayemain. In Togo, we thank Stanislas Tamekloe for assistance with the epidemiological data. We are also thankful to Kossivi Agbelenko Afanvi, Balanhewa Aguem-Massina, Amidou Sani, and Kwoami Dovi (MoH) for assistance in the field and discussions. We extend thanks to the UNICEF office in Lomé, Isselmou Boukhary, Fataou Salami, Tagba Assih, and Magali Romedenne. In Benin, the authors would like to extend gratitude to Gregoire Adadja, Nadine Agossa, and Adjakidje Senami Aurel (MoH) for assistance with the epidemiological data. We also thank Honore Bankole, Francois Hounsou, and Agnes Hounwanou from the Bacteriology Laboratory, Cotonou for discussion regarding the confirmation of patient V. cholerae isolates. We thank the staff at the UNICEF office in Cotonou: Mamadou Mouctar Baldé, Isabelle Sévédé-Bardem, Adama Ouedraogo, and Wilfried Houeto. In Ivory Coast, we would extend our gratitude to Bisimwa Ruhana Mirindi for organizing our field mission and important discussions. The researchers would like to thank Lindsey Osei (Aix-Marseille University) for assisting with establishment of the mission protocol. We thank Hélène Thefenne and Jean-Jacques Depina (L’Hopital d'Instruction des Armées Laveran, Marseille) for support with the V. cholerae isolates. The authors thank Lindsay Osei for helping to establish the protocol and initial collaborations with our colleagues in Ghana. We thank Dustin Robertson for assistance writing the manuscript. The authors thank Anne-Cécile Normand for assistance with the MLVA. Concerning the missions in Guinea and Sierra Leone, the authors thank all staff who took part in patient care, field investigations, data reporting as well as sample collection, transport, processing, and analysis. In particular, the authors are indebted to Sakoba Keita, Amara Jambai, and Leonard Heyerdahl (AMP, France). We are also grateful to H Diallo (INSP, Guinea) for performing initial vibrio cultures and the Aix-Marseille University staff who sequenced and analyzed the V. cholerae clone from Guinea. Finally, we are extremely grateful to all the families, village chiefs, fishermen, drivers, water vendors, and many others who took the time to explain to us their experience with cholera., Service de Santé des Armées-Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Institut de Recherche pour le Développement (IRD), National Institute of Hygiene, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), and Institut de Recherche Biomédicale des Armées (IRBA)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)
- Subjects
Bacterial Diseases ,lcsh:Arctic medicine. Tropical medicine ,Genotype ,lcsh:RC955-962 ,Minisatellite Repeats ,Pathology and Laboratory Medicine ,Ghana ,Microbiology ,Disease Outbreaks ,Sierra Leone ,Geographical Locations ,Cholera ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Vibrio Cholerae ,parasitic diseases ,Medicine and Health Sciences ,Benin ,Humans ,Epidemics ,Microbial Pathogens ,Phylogeny ,Vibrio ,Bacteria ,lcsh:Public aspects of medicine ,Mauritania ,Organisms ,Biology and Life Sciences ,lcsh:RA1-1270 ,Tropical Diseases ,Bacterial Pathogens ,Infectious Diseases ,Medical Microbiology ,Togo ,People and Places ,Africa ,Guinea ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Pathogens ,Research Article ,Neglected Tropical Diseases - Abstract
Background The countries of West Africa are largely portrayed as cholera endemic, although the dynamics of outbreaks in this region of Africa remain largely unclear. Methodology/Principal findings To understand the dynamics of cholera in a major portion of West Africa, we analyzed cholera epidemics from 2009 to 2015 from Benin to Mauritania. We conducted a series of field visits as well as multilocus variable tandem repeat analysis and whole-genome sequencing analysis of V. cholerae isolates throughout the study region. During this period, Ghana accounted for 52% of the reported cases in the entire study region (coastal countries from Benin to Mauritania). From 2009 to 2015, we found that one major wave of cholera outbreaks spread from Accra in 2011 northwestward to Sierra Leone and Guinea in 2012. Molecular epidemiology analysis confirmed that the 2011 Ghanaian isolates were related to those that seeded the 2012 epidemics in Guinea and Sierra Leone. Interestingly, we found that many countries deemed “cholera endemic” actually suffered very few outbreaks, with multi-year lulls. Conclusions/Significance This study provides the first cohesive vision of the dynamics of cholera epidemics in a major portion of West Africa. This epidemiological overview shows that from 2009 to 2015, at least 54% of reported cases concerned populations living in the three urban areas of Accra, Freetown, and Conakry. These findings may serve as a guide to better target cholera prevention and control efforts in the identified cholera hotspots in West Africa., Author summary We analyzed cholera epidemics from Benin to Mauritania, during 2009 to 2015, and performed a series of field visits as well as molecular epidemiology analyses of V. cholerae isolates from most recent epidemics throughout West Africa. We found that at least 54% of cases concerned populations living in the three urban areas of Accra, Freetown, and Conakry. Accra, Ghana represented the main cholera hotspot in the entire study region. Our findings indicate that the water network system in Accra may play a role in the rapid diffusion of cholera throughout the city. As observed in Accra, Conakry, and Freetown, once cholera cases arrive in overpopulated urban settings with poor sanitation, increased rainfall facilitated the contamination of unprotected water sources with human waste from cholera patients, thus promoting a rapid increase in cholera incidence. To more efficiently and effectively combat cholera in West Africa, these findings may serve as a guide to better target cholera prevention and control interventions.
- Published
- 2018
- Full Text
- View/download PDF