1. CAMPYLOBACTER JEJUNI LIPOPOLYSACCHARIDES FROM GUILLAIN‐BARRE SYNDROME PATIENTS INDUCE IGG ANTI‐GM1 ANTIBODIES IN RABBITS
- Author
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Jd Laman, Van Der Meche Fga, Hp Endtz, Pa Van Doorn, Ma De Klerk, Bc Jacobs, and Cw Ang
- Subjects
biology ,Guillain-Barre syndrome ,General Neuroscience ,bacterial infections and mycoses ,medicine.disease_cause ,biology.organism_classification ,medicine.disease ,Campylobacter jejuni ,Virology ,Epitope ,Microbiology ,Molecular mimicry ,biology.protein ,medicine ,bacteria ,lipids (amino acids, peptides, and proteins) ,Neurology (clinical) ,Antibody ,High titre - Abstract
Lipopolysaccharides (LPS) from Campylobacter jejuni strains isolated from patients with Guillain-Barre syndrome (GBS) display molecular mimicry with GM1. We immunized rabbits with C. jejuni LPS from GBS-associated strains containing a GM1-like epitope. All animals produced high titre anti-LPS antibodies that were cross-reactive with GM1. We conclude that C. jejuni strains from GBS patients are able to induce antibodies that cross-react with gangliosides and LPS. This study further confirms the role of molecular mimicry in the induction of anti-ganglioside antibodies in GBS patients.
- Published
- 2000
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