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1. Congeners of SMAP29 kill ovine pathogens and induce ultrastructural damage in bacterial cells.

Author

Kalfa VC, Jia HP, Kunkle RA, McCray PB Jr, Tack BF, and Brogden KA

Subjects
Amino Acid Sequence, Animals, Cathelicidins, Microbial Sensitivity Tests, Microscopy, Immunoelectron, Molecular Sequence Data, Anti-Bacterial Agents pharmacology, Bacteria drug effects, Bacteria ultrastructure, Blood Proteins pharmacology, Sheep microbiology, Sheep Diseases microbiology
Abstract

SMAP29, an ovine cathelicidin, was systematically altered to create a family of 23 related peptides for MIC and minimum bactericidal concentration determinations. SMAP28, SMAP29, and a derivative of SMAP29 called ovispirin were all antimicrobial. However, many congeners of SMAP29 and ovispirin were not as active as the parent molecules. With immunoelectron microscopy, SMAP29 was seen on membranes and within the cytoplasm of Pseudomonas aeruginosa PAO1.

Published
2001
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