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Objective: This study investigates reliability and validity of Turkish version of CDC Core Healthy Days Measures assessing health related quality of life (CDC HRQOL-4) in chronic low back pain (CLBP) patients. Methodology: One hundred eighty nine CLBP patients and 117 healthy controls participated. All respondents filled the following scales; the CDC HRQOL-4, Rolland Morris Questionnaire (RMQ), and the Hospital Anxiety and Depression Scale (HAD). Results: Cronbach's alpha of CDC HRQOL-4-items in CLBP patients was 0.69. Of 57.1% CLBP patients and 13.7% healthy controls defined their health status as fair or poor. The number of physically and mentally unhealthy days, and activity limitation days was found to be higher in the CLBP patients than the healthy controls (p<0.05). The CLBP patients with fair or poor health reported more physically unhealthy days, mentally unhealthy days, and activity limitation days than the CLBP patients with excellent, very good, or good health (p<0.05). Correlation coefficients between physically unhealthy days (r=0.30) and activity limitation days (r=0.22), and RMQ scores were significant, but low in magnitude. Moderate correlations between mentally unhealthy days and HAD scores (r=0.41 for anxiety; r=0.39 for depression) were found. Conclusion: The results of this study indicate that the Turkish version of the CDC HRQOL-4 is a short, reliable and valid tool to assess HRQOL in CLBP patients. [ABSTRACT FROM AUTHOR]