1. Immune functions of spleen lymphocytes of rats subjected to chronic irradiation and antioxidant (ubiquinone Q-9) diet.
- Author
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Novoselova EG, Safonova MV, Gordon RYa, and Semiletova NV
- Subjects
- Animals, Antioxidants administration & dosage, B-Lymphocytes drug effects, DNA analysis, DNA radiation effects, Diet, Dose-Response Relationship, Radiation, Flow Cytometry, Immune System physiology, Male, Radiation Dosage, Rats, Rats, Wistar, Spleen cytology, Spleen immunology, Spleen radiation effects, T-Lymphocytes drug effects, Ubiquinone administration & dosage, Antioxidants pharmacology, B-Lymphocytes immunology, B-Lymphocytes radiation effects, T-Lymphocytes immunology, T-Lymphocytes radiation effects, Ubiquinone pharmacology
- Abstract
The dynamics of T and B cell immunity in spleens from rat exposed to whole-body chronic irradiation with dose rates of 12.9 cGy/day (range 1-10 Gy) and 3.0 cGy/day (range 0.57-2.04 Gy) were investigated. gamma-irradiation with a dose-rate of 12.9 cGy/day was shown to produce a wave-like suppression of the T lymphocyte mitogenic response. Irradiation with a dose-rate of 3.0 cGy/day caused a decrease in immune response of T lymphocytes 48 days after onset of exposure (total dose 1.4 Gy). It was also shown that chronic irradiation with a dose-rate of 3.0 cGy/day produced significant changes in the DNA of T lymphocytes. Our results show that the radiation-induced suppression of immune functions and damage to DNA structure were partially eliminated when animals were fed a daily diet supplemented with a natural antioxidant, ubiquinone Q-9. The inhibiting effect of chronic irradiation was more pronounced in B lymphocytes because of their higher radiosensitivity.
- Published
- 1995
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