1. Monoclonal and oligoclonal immunoglobulins in the serum of patients with B-chronic lymphocytic leukemia.
- Author
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Pangalis GA, Moutsopoulos HM, Papadopoulos NM, Costello R, Kokkinou S, and Fessas P
- Subjects
- Bone Marrow pathology, Follow-Up Studies, Humans, Leukemia, Lymphoid pathology, Neoplasm Staging, Paraproteins classification, Plasma Cells pathology, B-Lymphocytes pathology, Leukemia, Lymphoid blood, Paraproteins analysis
- Abstract
The incidence of monoclonal and oligoclonal immunoglobulins (paraproteins) was determined in serum samples of 45 chronic lymphocytic leukemia (B-CLL) patients using the high-resolution agarose gel electrophoresis technique combined with immunofixation. Paraproteins were identified in 25 of the 45 patients tested. Twelve paraproteins were monoclonal and 13 oligoclonal. IgG kappa and/or lambda immunoglobulin isotypes were found in 17/25 of these patients. No correlation of the lymphocyte cell morphology and the presence of paraproteins was demonstrated. The high frequency of serum oligoclonal immunoglobulins in B-CLL indicates that more than one lymphocyte clone may be present in this disease.
- Published
- 1988
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