1. Accessory cells for β-cell transplantation.
- Author
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Staels, W., De Groef, S., Heremans, Y., Coppens, V., Van Gassen, N., Leuckx, G., Van de Casteele, M., Van Riet, I., Luttun, A., Heimberg, H., and De Leu, N.
- Subjects
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ANTIGEN presenting cells , *B cells , *TREATMENT of diabetes , *INSULIN therapy , *ARTIFICIAL pancreases , *GLYCEMIC control , *ISLANDS of Langerhans , *THERAPEUTICS - Abstract
Despite recent advances, insulin therapy remains a treatment, not a cure, for diabetes mellitus with persistent risk of glycaemic alterations and life-threatening complications. Restoration of the endogenous β-cell mass through regeneration or transplantation offers an attractive alternative. Unfortunately, signals that drive β-cell regeneration remain enigmatic and β-cell replacement therapy still faces major hurdles that prevent its widespread application. Co-transplantation of accessory non-islet cells with islet cells has been shown to improve the outcome of experimental islet transplantation. This review will highlight current travails in β-cell therapy and focuses on the potential benefits of accessory cells for islet transplantation in diabetes. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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