1. Gut Resistome of Preschool Children After Prolonged Mass Azithromycin Distribution: A Cluster-randomized Trial.
- Author
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Arzika, Ahmed M, Maliki, Ramatou, Abdou, Amza, Mankara, Alio K, Harouna, Abdoul N, Cook, Catherine, Hinterwirth, Armin, Worden, Lee, Zhong, Lina, Chen, Cindi, Ruder, Kevin, Zhou, Zhaoxia, Lebas, Elodie, O'Brien, Kieran S, Oldenburg, Catherine E, Le, Victoria, Arnold, Benjamin F, Porco, Travis C, Keenan, Jeremy D, and Lietman, Thomas M
- Subjects
CONFIDENCE intervals ,GUT microbiome ,COMMUNITY health services ,RANDOMIZED controlled trials ,TREATMENT effectiveness ,PLACEBOS ,COMPARATIVE studies ,DRUG monitoring ,DESCRIPTIVE statistics ,AZITHROMYCIN ,DRUG resistance in microorganisms ,STATISTICAL sampling ,CHILDREN - Abstract
We evaluated the gut resistome of children from communities treated with 10 twice-yearly azithromycin distributions. Although the macrolide resistance remained higher in the azithromycin arm, the selection of non-macrolide resistance observed at earlier time points did not persist. Longitudinal resistance monitoring should be a critical component of mass distribution programs. Clinical trials registration NCT02047981 [ABSTRACT FROM AUTHOR]
- Published
- 2021
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