1. [Study of the pharmacokinetics of phosphemide in rats with the use of physico-chemical methods].
- Author
-
Safonova TS, Presnova ZhF, Linberg LF, Chernov VA, and Kuriatov NS
- Subjects
- Animals, Antineoplastic Agents administration & dosage, Aziridines administration & dosage, Organophosphorus Compounds administration & dosage, Rats, Sarcoma, Experimental metabolism, Time Factors, Antineoplastic Agents metabolism, Aziridines metabolism, Azirines metabolism, Organophosphorus Compounds metabolism
- Abstract
A study on the passage of phosphemide with urine and distribution of the drug over the organs and tissues of intact (without fumour) rats and those with sarcoma-45 showed the bulk of unchanged drug to be excreted together with the urine during the first 3-4 hours following its intravenous and intraperitoneal administration. In rats with sarcoma-45 phosphamide is passed with urine in a somewhat greater amount than in the intact animals. With intravenous application the rate of the drug elimination in intact rats and in the ones with carcoma-45 is virtually the same, being somewhat lower with intraperitoneal injection of phosphemide.
- Published
- 1975