Search

The article assesses various studies which examine the adverse pregnancy and fetal outcomes after paternal exposure to oral immunosuppressive drugs azathioprine, methotrexate or mycophenolic acid. Topics discussed include the use of immunosuppressive drugs in dermatology, the considerations when assessing human pregnancy drug exposure data such as human embryology, tetralogy and pharmacology, and the limitations of the studies.

A letter to the editor is presented that discusses drug survival for azathioprine and enteric-coated mycophenolate sodium in a long-term daily practice cohort of adult patients with atopic dermatitis.

The article discusses research which examined the increased in liver enzyme levels during treatment of azathioprine (AZA), a purine antagonist used in chronic inflammatory skin diseases. Topics discussed include the influence of genetic polymorphisms in thiopurine-S-methyltransferase (TPMT) on the AZA metabolism and association of high TPMT activity with increased 6-methylmercaptopurine levels.