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This paper investigates the role of the horizontal axial force on the in-plane shear and flexural strength of masonry spandrels subjected to seismic actions. Strength criteria included in the main national and international codes take into account for geometrical and material properties, but valuable considerations about the influence of the horizontal axial force are missing. Nevertheless, experimental programs and post-earthquake damage scenarios proved that the horizontal axial force within the spandrels can be also significant under seismic actions, especially when they are surrounded by strength and stiff vertical piers or when significantly compressed by the effect of tensile-resistant elements. As main purpose, the strength criteria proposed by the Italian code for the spandrels have been revised accounting for the effect of the horizontal axial force on its shear and flexural strength. A database containing experimental tests conducted on masonry spandrels was elaborated and used to compare experimental with theoretical results. Outcomes showed that the revised criteria match satisfactorily the experimental results when significant axial forces affect the spandrels, both in terms of strength and failure mechanism. Contrariwise, existing code formulations are representative for the spandrels subjected to low axial force such that rocking or pure shear mechanisms tend to prevail.