1. Improvement in Cardiovascular Autonomic Neuropathy After High-Dose Vitamin D Supplementation in Patients With Type 1 Diabetes.
- Author
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Silva LSD, de Queiroz NNM, de Melo FTC, Abrahão Neto JF, Janaú LC, de Souza Neto NJK, de Lemos MN, de Oliveira MCNI, de Alcântara AL, de Moraes LV, da Silva WM, de Souza ÍJA, Said NM, de Lemos GN, Felício KM, Dos Santos MC, Motta ARB, Dos Reis MSO, Lobato IJC, de Figueiredo PBB, de Souza ACCB, Piani PPF, and Felício JS
- Subjects
- Adolescent, Adult, Autonomic Nervous System Diseases etiology, Autonomic Nervous System Diseases pathology, Blood Glucose analysis, Cardiovascular Diseases etiology, Cardiovascular Diseases pathology, Child, Diabetic Neuropathies etiology, Diabetic Neuropathies pathology, Female, Heart Rate, Humans, Male, Middle Aged, Pilot Projects, Prospective Studies, Vitamins administration & dosage, Young Adult, Autonomic Nervous System Diseases drug therapy, Cardiovascular Diseases drug therapy, Diabetes Mellitus, Type 1 complications, Diabetic Neuropathies drug therapy, Dietary Supplements, Vitamin D administration & dosage
- Abstract
Background: Cardiovascular autonomic neuropathy (CAN) is associated with diabetes mellitus , increasing morbidity and mortality. Some cross-sectional studies associated CAN with low 25-hydroxyvitamin D levels. The aim of our study was to evaluate the effect of high-dose vitamin D (VD) supplementation on CAN in Type 1 Diabetes Mellitus (T1DM) patients., Methods: We performed a prospective study with 23 patients diagnosed with T1DM and CAN. Subjects with VD levels <30 ng/ml received 10,000 IU/day; the ones with VD levels between 30-60 ng/ml were given 4,000 IU/day for 12 weeks., Results: There was an improvement in CAN parameters related to resting heart rate variability, such as time domain parameters [Maximum RR interval (0.77 ± 0.11 vs 0.94 ± 0.51 s, p <0.05), Mean length of regular RR intervals (0.71 ± 0.10 vs 0.76 ± 0.09 s, p <0.05) and Standard deviation of all NN intervals (0.02 ± 0.01 vs 0.03 ± 0.02 s; p <0.01)] and frequency domain parameters [Low Frequency (1.9 ± 0.5 vs 2.5 ± 0.9 s, p < 0.001), Total Power (2.5 ± 0.4 vs 2.8 ± 0.6 s, p <0.05)]. In addition, there was a correlation between absolute VD level variation and posttreatment High Frequency (%), as well as among percent variation in VD level and end-of-study Low Frequency/High Frequency ratio (r=0.6, p<0.01; r= -0.5, p<0.05, respectively)., Conclusion: Our pilot study is the first to suggest a strong association between high-dose vitamin D supplementation and improved cardiovascular autonomic neuropathy in T1DM patients. It occurred without any variation in HbA1C, blood pressure levels, lipids, and insulin dose., Clinical Trial Registration: http://www.isrctn.com/ISRCTN32601947, identifier ISRCTN32601947., (Copyright © 2020 Silva, de Queiroz, de Melo, Abrahão Neto, Janaú, de Souza Neto, de Lemos, de Oliveira, de Alcântara, de Moraes, da Silva, de Souza, Said, de Lemos, Felício, Santos, Motta, dos Reis, Lobato, de Figueiredo, de Souza, Piani and Felício.)
- Published
- 2020
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