1. An autosomal genome-wide screen for celiac disease in Bedouin families.
- Author
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Ding, Y. C., Weizman, Z., Yerushalmi, B., Elbedour, K., Garner, C. P., and Neuhausen, S. L.
- Subjects
CELIAC disease ,BEDOUINS ,AUTOIMMUNE diseases ,GLUTEN-free diet ,MICROSATELLITE repeats ,IMMUNITY ,GENETICS education - Abstract
Celiac disease is a common, familial autoimmune disease caused by exposure to gliadin in wheat, and related prolamins in barley and rye. The prevalence of the disease is approximately 1:133. Celiac disease can cause significant morbidity. The only treatment is a gluten-free diet. A genome-wide search of 405 microsatellite markers was performed on samples from 18 Bedouin families with a minimum of two cases of celiac disease. Non-parametric and parametric (including both dominant and recessive models of inheritance) linkage analyses were performed. The most significant genome-wide linkage evidence was at chromosome 3p26 with an HLod of 3.21, under the dominant model. The only other HLod or NPL greater than 2 was at 4q35, with an HLod of 2.15 under a dominant model. The region at 3p26, previously reported in two linkage analyses, harbors interleukin receptor genes, plausible candidates for celiac disease.Genes and Immunity (2008) 9, 81–86; doi:10.1038/sj.gene.6364439; published online 18 October 2007 [ABSTRACT FROM AUTHOR]
- Published
- 2008
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