1. Sjögren’s Syndrome Complicated with Type 2 Autoimmune Hepatitis: A Case Report-Based Review of the Literature
- Author
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Muhammad Sohaib Asghar, Abubakar Tauseef, Narmin Khan, Maryam Zafar, Uzma Rasheed, and Maira Hassan
- Subjects
antinuclear antibody (ana) ,anti-liver–kidney microsomal (lkm) ,autoimmune ,hepatitis ,sjögren’s disease ,splenomegaly ,Medicine - Abstract
This case details a 33-year-old female who presented with a suggestive autoimmune history, arthralgias, and splenomegaly, and tested positive for Sjögren’s syndrome and anti-liver–kidney microsomal antibody. This was further validated by findings from a liver biopsy, confirming a very rare association with Type 2 autoimmune hepatitis. Primary Sjögren’s syndrome is a sporadic disease with a global prevalence of 61 per 100,000 people and a total prevalence of 0.4% for secondary Sjögren’s syndrome. The prevalence of autoimmune hepatitis in association with primary Sjögren’s syndrome is 4–47%. It is divided into two types, associated with characteristic antibodies. Type 2 autoimmune hepatitis is rarely reported with Sjögren’s syndrome; much of the association reported in the literature has been with Type 1 autoimmune hepatitis.
- Published
- 2020
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