1. Markedly elevated GAD antibodies in SPS: effects of age and illness duration.
- Author
-
Murinson BB, Butler M, Marfurt K, Gleason S, De Camilli P, and Solimena M
- Subjects
- Age Factors, Antibody Specificity, Autoantibodies immunology, Autoimmune Diseases blood, Blotting, Western, Cohort Studies, Humans, Immunohistochemistry, Predictive Value of Tests, ROC Curve, Sensitivity and Specificity, Stiff-Person Syndrome blood, Time Factors, gamma-Aminobutyric Acid biosynthesis, gamma-Aminobutyric Acid physiology, Autoantibodies blood, Autoantigens immunology, Autoimmune Diseases immunology, Glutamate Decarboxylase immunology, Radioimmunoassay, Stiff-Person Syndrome immunology
- Abstract
Five hundred seventy-six patients with suspected stiff-person syndrome (SPS) underwent immunocytochemistry (ICC). Of these, 286 underwent radioimmunoassay (RIA) for glutamic acid decarboxylase (GAD) antibodies; 116 were GAD antibody positive by one or both tests. Ninety-six percent of those positive by ICC had RIA values several standard deviations above normal. RIA did not correlate with age or illness duration. Marked elevations of RIA for GAD antibodies were characteristic of ICC-confirmed SPS, and modest elevations were not.
- Published
- 2004
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