1. Partial remission in Brazilian children and adolescents with type 1 diabetes. Association with a haplotype of class II human leukocyte antigen and synthesis of autoantibodies.
- Author
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Camilo DS, Pradella F, Paulino MF, Baracat ECE, Marini SH, Guerra G Jr, Pavin EJ, Parisi C, Longhini ALF, Marques SB, Guariento EG, Lieber SR, Macedo CF, Gama E Silva L, Farias AS, Santos LMB, and Volpini WMG
- Subjects
- Adolescent, Adult, Autoantibodies genetics, Brazil epidemiology, Case-Control Studies, Child, Child, Preschool, Female, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, HLA-DQ Antigens genetics, HLA-DRB1 Chains genetics, Haplotypes, Humans, Infant, Male, Remission, Spontaneous, Young Adult, Autoantibodies biosynthesis, Diabetes Mellitus, Type 1 epidemiology, Diabetes Mellitus, Type 1 genetics, Diabetes Mellitus, Type 1 immunology, Diabetes Mellitus, Type 1 pathology, Histocompatibility Antigens Class II genetics
- Abstract
Objective: Characterization of partial remission using the insulin dose-adjusted HbA1c (IDAA1c) ≤ 9 definition in a multiethnic Brazilian population of children and adolescents with type 1 diabetes (T1D), in addition with the determination of both Class II HLA genotype and autoantibodies., Methods: We analyzed the prevalence of partial remission in 51 new-onset T1D patients with a median time follow-up of 13 months from diagnosis. For this study, anti-GAD65, anti-IA2 and HLA class II genotyping were considered., Results: Partial remission occurred in 41.2% of T1D patients until 3 months after diagnosis, mainly in those aged 5-15 years. We have demonstrated a significant increase in the haplotypes of class II HLA DRB1*0301-DQB1*0201 in children and adolescents with a partial remission phase of the disease (42.9% vs 21.7% in non-remitters, P = .0291). This haplotype was also associated with the reduction of anti-IA2 antibodies production. Homozygote DRB1*03-DQB1*0201/DRB1*03-DQB1*0201 children had the lowest prevalence of IA-2A antibodies (P = .0402). However, this association does not correlate with the time of the remission phase., Conclusion: Although the number of patients studied was reduced, our data suggested that the association between genetics and decrease in antibody production to certain islet auto-antigen may contribute, at least in part, to the remission phase of T1D., (© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2020
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