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Your search keyword '"Ruta, L."' showing total 4 results
Start Over Author "Ruta, L." Topic autism
4 results on '"Ruta, L."'

1. Elevated fetal steroidogenic activity in autism

Author

Baron-Cohen, Simon, Auyeung, Bonnie, Nørgaard-Pedersen, B., Hougaard, D. M., Abdallah, M. W., Melgaard, L., Cohen, A. S., Chakrabarti, B., Ruta, L., Lombardo, Michael V., and Lombardo, Michael V. [0000-0001-6780-8619]

Subjects
Male, medicine.medical_specialty, Hydrocortisone, Denmark, Gestational Age, Cohort Studies, 03 medical and health sciences, Cellular and Molecular Neuroscience, Fetus, 0302 clinical medicine, Tandem Mass Spectrometry, Internal medicine, medicine, Humans, Asperger Syndrome, Autistic Disorder, Molecular Biology, Testosterone, 030304 developmental biology, Pervasive developmental disorder not otherwise specified, Analysis of Variance, Principal Component Analysis, 0303 health sciences, Case-control study, medicine.disease, 3. Good health, Psychiatry and Mental health, Endocrinology, Asperger syndrome, Case-Control Studies, Autism, Female, Steroids, Original Article, Psychology, 030217 neurology & neurosurgery, Chromatography, Liquid, medicine.drug, Hormone
Abstract

Autism affects males more than females, giving rise to the idea that the influence of steroid hormones on early fetal brain development may be one important early biological risk factor. Utilizing the Danish Historic Birth Cohort and Danish Psychiatric Central Register, we identified all amniotic fluid samples of males born between 1993 and 1999 who later received ICD-10 (International Classification of Diseases, 10th Revision) diagnoses of autism, Asperger syndrome or PDD-NOS (pervasive developmental disorder not otherwise specified) (n=128) compared with matched typically developing controls. Concentration levels of Δ4 sex steroids (progesterone, 17α-hydroxy-progesterone, androstenedione and testosterone) and cortisol were measured with liquid chromatography tandem mass spectrometry. All hormones were positively associated with each other and principal component analysis confirmed that one generalized latent steroidogenic factor was driving much of the variation in the data. The autism group showed elevations across all hormones on this latent generalized steroidogenic factor (Cohen's d=0.37, P=0.0009) and this elevation was uniform across ICD-10 diagnostic label. These results provide the first direct evidence of elevated fetal steroidogenic activity in autism. Such elevations may be important as epigenetic fetal programming mechanisms and may interact with other important pathophysiological factors in autism. © 2015 Macmillan Publishers Limited. 20 3 369 376 Cited By :73; Export Date: 17 July 2017

Published
2014
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2. Autism and lack of D3 vitamin: A systematic review.

Author

Pioggia, G., Tonacci, A., Tartarisco, G., Billeci, L., Muratori, F., Ruta, L., and Gangemi, S.

Abstract

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by social communication deficits and restricted, repetitive patterns of behavior. Several medical conditions including gastrointestinal (GI) problems, asthma and allergies have been associated with ASD, and multiple risk factors, both genetic and environmental, have been proposed. Among them, vitamin D (VD) deficiency is probably associated with ASD, and may play a role in the condition. We conducted a systematic review of the literature for the period January 1, 2010 through June 15, 2014, according to PRISMA guidelines, aiming to investigate the complex biological interplay between VD, metabolism, immune system and nervous system in ASD. Different trends in the association between ASD and VD deficiency have been observed, and factors such as gender, ethnicity, sampling, and methodology play a role in the results and outcomes. At present, for at least a subgroup of ASD individuals, an imbalance in VD metabolism probably exists and may be associated with the condition. In this cohort, VD replacement in these individuals might contribute to improving ASD symptoms and/or associated conditions. This topic is an important challenge for future research, and could lead to a new tailored therapeutic approach for VD in ASD. [ABSTRACT FROM AUTHOR]

Published
2014
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3. Non-intrusive and calibration free visual exploration analysis in children with autism spectrum disorder

Author

Cazzato, D., Adamo, F., Palestra, G., Crifaci, G., Pennisi, P., Giovanni Pioggia, Ruta, L., Leo, M., and Distante, C.

Subjects
gaze analysis, Autism, assistive technology
Abstract

Assistive technology is a generic system that is used to increase, help or improve the functional capabilities of people with disability. Recently, its employment has generated innovative solutions also in the field of Autism Spectrum Disorder (ASD), where it is extremely challenging to obtain feedback or to extract meaningful data. In this work, a study about the possibility to understand the visual exploration in children with ASD is presented. In order to obtain an automatic evaluation, an algorithm for free gaze estimation is employed. The proposed gaze estimation method can work without constrains nor using additional hardware, IR light sources or other intrusive methods. Furthermore, no initial calibration is required. These relaxations of the constraints makes the technique particularly suitable to be used in the critical context of autism, where the child is certainly not inclined to employ invasive devices. In particular, the technique is used in a scenario where a closet containing specific toys, that are neatly disposed from the therapist, is opened to the child. After a brief environment exploration, the child will freely choose the desired toy that will be subsequently used during therapy. The video acquisition have been accomplished by a Microsoft Kinect sensor hidden into the closet in order to obtain both RGB and depth images, that can be processed by the estimation algorithm, therefore computing gaze tracking by intersection with data coming from the well-known initial disposition of toys. The system has been tested with children with ASD, allowing to understand their choices and preferences, letting to optimize the toy disposition for cognitive-behavioural therapy.

4. Genetic and functional analyses of SHANK2 mutations suggest a multiple hit model of autism spectrum disorders

Author

Christian Proepper, Dominique Bonneau, Catalina Betancur, Sarah Curran, Astrid M. Vicente, Henrik Anckarsäter, Elena Bacchelli, Sabine M. Klauck, Eftichia Duketis, Guiomar Oliveira, Fabien Fauchereau, Richard Delorme, Irma Järvelä, I. Carina Gillberg, Marina Konyukh, Stephen W. Scherer, Pauline Chaste, Elena Maestrini, Guillaume Huguet, Dalila Pinto, David Skuse, Marie-Christine Mouren, Béatrice Regnault, Nathalie Lemière, Jonas Melke, Christopher Gillberg, Bárbara Oliveira, Maria Råstam, Thomas Bourgeron, Marnie Kopp, Marc Delepine, Oriane Mercati, Raija Vanhala, Luigi Mazzone, Marion Leboyer, Richard Holt, Agatino Battaglia, Fiorella Minopoli, Katri Kantojärvi, Diana Zelenika, Liliana Ruta, Roberto Toro, Ana Filipa Sequeira, Françoise Devillard, Brigitte Assouline, Martin Poot, Elodie Ey, Regina Waltes, Vincent Guinchat, Tobias M. Boeckers, Jutta Heinrich, Anthony P. Monaco, Gudrun Nygren, Fritz Poustka, Mark Lathrop, David A. Collier, Claire S. Leblond, Patrick Bolton, Christine M. Freitag, Andreas G. Chiocchetti, Betancur, Catalina, Génétique Humaine et Fonctions Cognitives, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Universität Ulm - Ulm University [Ulm, Allemagne], Service de psychopathologie de l'enfant et de l'adolescent, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), Physiopathologie des Maladies du Système Nerveux Central, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Department of Child and Adolescent Psychiatry, University of Gothenburg (GU), Forensic Psychiatry, Lund University [Lund], Department of Pharmacology, Génotypage des Eucaryotes (Plate-Forme), Institut Pasteur [Paris] (IP), Behavioural and Brain Sciences Unit, Institute of Child Health, University College of London [London] (UCL), University Medical Center [Utrecht], The Wellcome Trust Centre for Human Genetics [Oxford], University of Oxford, Department of Medical and Clinical Genetics [Helsinki], Haartman Institute [Helsinki], Faculty of Medecine [Helsinki], Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Faculty of Medecine [Helsinki], Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Academic Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King‘s College London, Social, Genetic and Developmental Psychiatry Centre (SGDP), Institute of psychiatry, Division of Molecular Genome Analysis, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Goethe-Universität Frankfurt am Main, Department of Pharmacy and Biotechnology, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Institute of Biotechnology, Department of Psychiatry and Behavioral Sciences [Stanford], Stanford Medicine, Stanford University-Stanford University, Division of Child Neurology and Psychiatry, Department of Paediatrics, Università degli studi di Catania = University of Catania (Unict), Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal] (INSA), BioFIG, Center for Biodiversity, Functional and Integrative Genomics, Unidade de Neurodesenvolvimento e Autismo (UNDA), Hospital Pediatrico de Coimbra, Human Genetics Center, The University of Texas Health Science Center at Houston (UTHealth), The Centre for Applied Genomics, Toronto, The Hospital for sick children [Toronto] (SickKids)-University of Toronto-Department of Molecular Genetics-McLaughlin Centre, Program in Genetics and Genomic Biology, Hospital for Sick Children-University of Toronto McLaughlin Centre, Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Biologie Neurovasculaire Intégrée (BNVI), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Unité Pédopsychiatrique et Neuropédiatrique de Diagnostic et d'Evaluation des Troubles Envahissants du Développement, Centre Alpin de DIagnostic Précoce de l'Autisme - CADIPA-Centre Hospitalier Alpes Isère, Département de génétique et procréation, Université Joseph Fourier - Grenoble 1 (UJF)-Hôpital Couple-Enfant, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institute for Anatomy and Cell Biology, Department of Medical and Clinical Genetics, Leblond C.S., Heinrich J., Delorme R., Proepper C., Betancur C., Huguet G., Konyukh M., Chaste P| Ey E., Rastam M., Anckarsäter H., Nygren G., Gillberg IC., Melke J., Toro R., Regnault B., Fauchereau F., Mercati O., Lemière N., Skuse D., Poot M., Holt R., Monaco A.P., Järvelä I., Kantojärvi K., Vanhala R., Curran S., Collier D.A., Bolton P., Chiocchetti A., Klauck S.M., Poustka F., Freitag C.M., Waltes R., Kopp M., Duketis E., Bacchelli E., Minopoli F., Ruta L., Battaglia A., Mazzone L., Maestrini E., Sequeira A.F., Oliveira B., Vicente A., Oliveira G., Pinto D., Scherer S.W., Zelenika D., Delepine M., Lathrop M., Bonneau D., Guinchat V., Devillard F., Assouline B., Mouren M.C., Leboyer M., Gillberg C., Boeckers T.M., Bourgeron T., Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Institute of Anatomy and Cell Biology, Ulm University, University of Lund, Institut Pasteur [Paris], University of Oxford [Oxford], University of Helsinki-University of Helsinki-Faculty of Medecine [Helsinki], University of Helsinki-University of Helsinki, Università degli studi di Catania [Catania], and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10

Subjects
Male, Gene Dosage, Receptors, Nicotinic, MESH: Protein Isoforms, HIDDEN-MARKOV MODEL, 0302 clinical medicine, MESH: Child, Protein Isoforms, Tissue Distribution, MESH: Nerve Tissue Proteins, Child, Neurons, 0303 health sciences, MESH: Alternative Splicing, PSYCHIATRIC-DISORDERS, CHRNA7, MESH: Sequence Deletion, 3. Good health, Autism spectrum disorder, Child, Preschool, Medicine, Adaptor Proteins, Signal Transducing, Adult, Alternative Splicing, Cell Line, Child Development Disorders, Pervasive, Female, Gene Expression Regulation, Humans, Nerve Tissue Proteins, RNA Splice Sites, Sequence Deletion, Synapses, alpha7 Nicotinic Acetylcholine Receptor, Child Development Disorders, education, COPY-NUMBER VARIATION, Molecular Genetics, 03 medical and health sciences, Genetics, AUTISM, MESH: Tissue Distribution, Molecular Biology, Biology, SNP GENOTYPING DATA, Ecology, Evolution, Behavior and Systematics, Pervasive, MESH: Adaptor Proteins, Signal Transducing, [SDV.GEN]Life Sciences [q-bio]/Genetics, MESH: Humans, RECURRENT MICRODELETIONS, MESH: Child, Preschool, Signal Transducing, MESH: Adult, SCAFFOLDING PROTEIN SHANK3, medicine.disease, Human genetics, MESH: Cell Line, MESH: Female, 030217 neurology & neurosurgery, Neuroscience, Cancer Research, MESH: Neurons, MESH: RNA Splice Sites, [SDV.GEN] Life Sciences [q-bio]/Genetics, Bioinformatics, Nicotinic, MESH: Child Development Disorders, Pervasive, MESH: Gene Dosage, MESH: Synapses, POSTSYNAPTIC DENSITY, Receptors, Copy-number variation, Genetics (clinical), Psychiatry, Adaptor Proteins, MESH: Gene Expression Regulation, Settore MED/39 - Neuropsichiatria Infantile, SHANK2, Mental Health, MESH: Receptors, Nicotinic, Research Article, lcsh:QH426-470, 15Q13.3 MICRODELETIONS, Genetic variation, mental disorders, medicine, ddc:610, Preschool, Gene, 030304 developmental biology, MESH: Male, lcsh:Genetics, DE-NOVO MUTATIONS, Perturbações do Desenvolvimento Infantil e Saúde Mental, biology.protein, Autism, 3111 Biomedicine, MENTAL-RETARDATION
Abstract

Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders with a complex inheritance pattern. While many rare variants in synaptic proteins have been identified in patients with ASD, little is known about their effects at the synapse and their interactions with other genetic variations. Here, following the discovery of two de novo SHANK2 deletions by the Autism Genome Project, we identified a novel 421 kb de novo SHANK2 deletion in a patient with autism. We then sequenced SHANK2 in 455 patients with ASD and 431 controls and integrated these results with those reported by Berkel et al. 2010 (n = 396 patients and n = 659 controls). We observed a significant enrichment of variants affecting conserved amino acids in 29 of 851 (3.4%) patients and in 16 of 1,090 (1.5%) controls (P = 0.004, OR = 2.37, 95% CI = 1.23–4.70). In neuronal cell cultures, the variants identified in patients were associated with a reduced synaptic density at dendrites compared to the variants only detected in controls (P = 0.0013). Interestingly, the three patients with de novo SHANK2 deletions also carried inherited CNVs at 15q11–q13 previously associated with neuropsychiatric disorders. In two cases, the nicotinic receptor CHRNA7 was duplicated and in one case the synaptic translation repressor CYFIP1 was deleted. These results strengthen the role of synaptic gene dysfunction in ASD but also highlight the presence of putative modifier genes, which is in keeping with the “multiple hit model” for ASD. A better knowledge of these genetic interactions will be necessary to understand the complex inheritance pattern of ASD., Author Summary Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders with a complex inheritance pattern. While mutations in several genes have been identified in patients with ASD, little is known about their effects on neuronal function and their interaction with other genetic variations. Using a combination of genetic and functional approaches, we identified novel SHANK2 mutations including a de novo loss of one copy of the SHANK2 gene in a patient with autism and several mutations observed in patients that reduced neuronal cell contacts in vitro. Further genomic analysis of three patients carrying de novo SHANK2 deletions identified additional rare genomic imbalances previously associated with neuropsychiatric disorders. Taken together, these results strengthen the role of synaptic gene dysfunction in ASD but also highlight the presence of putative modifier genes, which is in keeping with the “multiple hit model” for ASD. A better knowledge of these genetic interactions will be necessary to understand the complex inheritance pattern of ASD.

Published
2012
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