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Adaptive behavior was measured over time in 70 children, ages 1 to 12 years, with fragile X syndrome. With a mean of 4.4 assessments per child, adaptive behavior skills increased steadily and gradually over time. Children with less autistic behavior and higher percentages of the fragile X mental retardation gene protein showed better performance on all areas of adaptive behavior. (Contains references.) (Author/DB)

Direct observational data were collected on the behavior of 26 elementary school-age boys with fragile X syndrome (FXS), the most prevalent inherited cause of mental retardation, during classroom academic activities. Findings indicated classroom engagement comparable to that of peers and not related to intrasubject variables such as severity of developmental delay, autism status, or medication usage. (Contains references.) (Author/DB)

A study of 57 boys with fragile X syndrome (ages 24-133 months) assessed the extent to which autism and autistic features were evident using the Childhood Autism Rating Scale (CARS). Fourteen subjects scored above the cut-off for autism, with 12 of the 14 in the mildly or moderately autistic range. (Author/CR)