1. Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC.
- Author
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Shohayeb B, Mitchell N, Millard SS, Quinn LM, and Ng DCH
- Subjects
- Animals, Brain growth & development, Brain metabolism, Cell Proliferation genetics, Drosophila genetics, Drosophila growth & development, Neurogenesis genetics, Neuroglia metabolism, Proto-Oncogene Proteins c-akt genetics, Signal Transduction genetics, Spindle Apparatus genetics, Aurora Kinase A genetics, DNA-Binding Proteins genetics, Drosophila Proteins genetics, Nerve Tissue Proteins genetics, Transcription Factors genetics
- Abstract
WD40-Repeat Protein 62 (WDR62) is required to maintain neural and glial cell populations during embryonic brain growth. Although elevated expression of WDR62 is frequently associated with several tumour types, potential effects of excess WDR62 on proliferative growth remain undefined. Here, we demonstrate that glia specific overexpression of WDR62 in Drosophila larval brains resulted in increased cell size, over-proliferation and increased brain volume, without overt disruption of tissue organization. We further demonstrate WDR62 promoted over-proliferation and brain overgrowth by activating AURKA and pAKT signalling to increase MYC function in glial cells. Together these data suggest WDR62 normally functions in the glial lineage to activate oncogenic signalling networks, promoting proliferation and brain overgrowth., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Crown Copyright © 2020. Published by Elsevier B.V. All rights reserved.)
- Published
- 2020
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