1. Relationships among tau burden, atrophy, age, and naming in the aphasic variant of Alzheimer's disease.
- Author
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Martersteck A, Sridhar J, Coventry C, Weintraub S, Mesulam MM, and Rogalski E
- Subjects
- Age Factors, Aged, Alzheimer Disease pathology, Brain Cortical Thickness, Female, Humans, Male, Positron-Emission Tomography, Temporal Lobe pathology, Aphasia, Primary Progressive diagnostic imaging, Aphasia, Primary Progressive pathology, Atrophy pathology, Brain pathology, Language Tests statistics & numerical data, tau Proteins metabolism
- Abstract
Introduction: Examination of pathologic, anatomic, and cognitive relationships has been limited in primary progressive aphasia (PPA) with underlying Alzheimer's disease (AD) neuropathology., Methods: Spatial relationships between tau positron emission tomography (PET), cortical thickness, age, and naming on the Boston Naming Test (BNT) in PPA with biomarker evidence of AD (PPA-AD) were examined., Results: Higher tau PET burden was associated with atrophy and younger age. There was a significant left-lateralized relationship between lower BNT and more atrophy, and between lower BNT and increased tau burden. Variance in naming was primarily shared between tau and atrophy (51%), but naming was uniquely explained more by atrophy (32%) than tau (16%). Higher left anterior temporal tau burden was associated with greater 1-year rate of decline in naming., Discussion: PPA-AD has a similar relationship between abnormal biomarkers as first described in amnestic AD, with differing spatial extent, reflecting the left-lateralized nature of the language network., (© 2021 the Alzheimer's Association.)
- Published
- 2021
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