1. Dupilumab for atopic dermatitis during pregnancy and breastfeeding: Clinical experience in 13 patients.
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Escolà, H., Figueras‐Nart, I., Bonfill‐Orti, M., Coll Puigserver, N., Martin‐Santiago, A., Rodríguez Serna, M., Sánchez Hernández, M. C., Sanz‐Cabanillas, J. L., Taberner, R., Zaragoza‐Ninet, V., Pujol, R. M., and Curto‐Barredo, L.
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ATOPIC dermatitis ,DUPILUMAB ,PREGNANCY ,ANKYLOGLOSSIA ,BREASTFEEDING ,PATIENTS' attitudes - Abstract
Patients' characteristics, treatments received before dupilumab, reasons that led to initiate this treatment as well as the cause of treatment discontinuation are mentioned in Table 1. Duration of 9 month during pregnancy and 1 month during breastfeeding
- Patient 12 34 25 Caucasian Asthma Topical and systemic corticosteroids, cyclosporine Unknown Before pregnancy Shared decision-making was adopted after a risk-benefit assessment, discussing the course of AD, safety data, potential therapeutic options and previous response to systemic treatments Left the treatment. [Extracted from the article] - Published
- 2023
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2. Treatment of moderate‐to‐severe atopic dermatitis with dupilumab in real clinical practice: a multicentre, retrospective case series.
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Armario‐Hita, J.C., Pereyra‐Rodriguez, J., Silvestre, J.F., Ruiz‐Villaverde, R., Valero, A., Izu‐Belloso, R., Jáuregui‐Presa, I., Curto‐Barredo, L., Figueras‐Nart, I., Herranz‐Pinto, P., Herraez‐Herrera, L., Ortiz‐de‐Frutos, F.J., Martinez‐Pilar, L., Sastre, J., and Serra‐Baldrich, E.
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ATOPIC dermatitis ,MEDICAL practice ,ALLERGIC rhinitis ,THERAPEUTICS - Abstract
Dear Editor, Atopic dermatitis (AD) is a chronic, inflammatory and pruritic skin disease, with a prevalence of 1-3% of the adult population.[1] The physiopathology of AD is multifactorial, with interaction of genetic disposition and environmental triggers coexisting with a marked skin barrier dysfunction and type 2-driven immune dysregulation. GLO:F03/01nov19:bjd18041-fig-0001.jpg PHOTO (COLOR): Mean percentage change in Eczema Area and Severity Index (EASI), Scoring Atopic Dermatitis (SCORAD) and pruritus visual analogue scale (VAS) scores from baseline through week 24 in patients treated with dupilumab. gl Dupilumab improved significantly the signs and symptoms of AD, measured by EASI, SCORAD and pruritus VAS, as well as quality of life. [Extracted from the article]
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- 2019
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3. Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients
- Author
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Sans-de San Nicolàs, Lídia, Figueras-Nart, Ignasi, García-Jiménez, Irene, Bonfill-Ortí, Montserrat, Guilabert, Antonio, Curto-Barredo, Laia, Bertolín-Colilla, Marta, Ferran, Marta, Serra-Baldrich, Esther, Pujol, Ramon M., Santamaria-Babí, Luis F., Universitat Autònoma de Barcelona, [Sans-de San Nicolàs L, García-Jiménez I] Immunologia Translacional, Departament de Biologia Cel·lular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona (UB), Parc Científic de Barcelona (PCB), Barcelona, Spain. [Figueras-Nart I, Bonfill-Ortí M] Departament de Dermatologia, Hospital de Bellvitge, Universitat de Barcelona (UB), L’Hospitalet de Llobregat, Spain. [Guilabert A] Departament de Dermatologia, Hospital General de Granollers, Granollers, Spain. [Curto-Barredo L] Departament de Dermatologia, Hospital del Mar, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain, and Hospital General de Granollers
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Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Genetic Diseases, Inborn::Skin Diseases, Genetic::Dermatitis, Atopic [DISEASES] ,enfermedades de la piel y tejido conjuntivo::enfermedades de la piel::prurito [ENFERMEDADES] ,CLA + memory T cells ,Al·lèrgens ,Pruritus ,Pruïja ,Immunology ,T cells ,Hemic and Immune Systems::Hemic and Immune Systems::Immune System::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes [ANATOMY] ,IL-31 ,sistemas sanguíneo e inmunológico::sistemas sanguíneo e inmunológico::sistema inmunológico::leucocitos::leucocitos mononucleares::linfocitos::linfocitos T [ANATOMÍA] ,Allergens ,House dust mite ,Periostin ,enfermedades y anomalías neonatales congénitas y hereditarias::enfermedades genéticas congénitas::enfermedades cutáneas genéticas::dermatitis atópica [ENFERMEDADES] ,Cèl·lules T ,Citocines ,CCL27 ,Cytokines ,Immunology and Allergy ,Skin and Connective Tissue Diseases::Skin Diseases::Pruritus [DISEASES] ,IgE ,Dermatitis atòpica ,Atopic dermatitis - Abstract
BackgroundThe role of allergen sensitization in IL-31 production by T cells and specifically in the clinical context of atopic dermatitis (AD) has not been characterized.MethodsThe response to house dust mite (HDM) in purified memory T cells cocultured with epidermal cells from AD patients (n=58) and control subjects (n=11) was evaluated. AD-associated cytokines from culture supernatants, plasma proteins and mRNA expression from cutaneous lesions were assessed and related with the clinical features of the patients.ResultsHDM-induced IL-31 production by memory T cells defined two subsets of AD patients according to the presence or absence of IL-31 response. Patients in the IL-31 producing group showed a more inflammatory profile, and increased HDM-specific (sp) and total IgE levels compared to the IL-31 non-producing group. A correlation between IL-31 production and patient’s pruritus intensity, plasma CCL27 and periostin was detected. When the same patients were analyzed based on sp IgE and total IgE levels, an increased IL-31 in vitro response, as well as type 2 markers in plasma and cutaneous lesions, was found in patients with sp IgE levels > 100 kUA/L and total IgE levels > 1000 kU/L. The IL-31 response by memory T cells was restricted to the cutaneous lymphocyte-associated antigen (CLA)+ T-cell subset.ConclusionIgE sensitization to HDM allows stratifying IL-31 production by memory T cells in AD patients and relating it to particular clinical phenotypes of the disease.
- Published
- 2023
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