1. Carotid Plaques Correlates in Patients With Familial Hypercholesterolemia.
- Author
-
Waluś-Miarka M, Czarnecka D, Wojciechowska W, Kloch-Badełek M, Kapusta M, Sanak M, Wójcik M, Małecki MT, Starzyk J, and Idzior-Waluś B
- Subjects
- Adult, Aged, Atherosclerosis blood, Blood Pressure physiology, Female, Humans, Hyperlipoproteinemia Type II diagnosis, Hyperlipoproteinemia Type II metabolism, Male, Middle Aged, Risk Factors, Young Adult, Apolipoproteins B blood, Atherosclerosis complications, Carotid Intima-Media Thickness, Cholesterol, HDL blood, Hyperlipoproteinemia Type II complications, Lipoproteins, HDL metabolism
- Abstract
Patients with familial hypercholesterolemia (FH) are at increased risk of premature cardiovascular disease. We compared factors associated with the presence of carotid plaques and carotid intima-media thickness (cIMT), markers of subclinical atherosclerosis, in 241 patients with FH (98, 40.7% men; mean age 41 ± 18.4 years). Patients with FH having carotid plaques (36.5%) had mean age, apolipoprotein (apo) B, glucose, apoA1, systolic blood pressure (SBP) and diastolic BP, waist/hip ratio (WHR), and body mass index higher than patients without plaques. Logistic regression revealed that apoB (odds ratio [OR] per 1 unit change 1.03,P= .005), high-density lipoprotein cholesterol (HDL-C; OR per 1 standard deviation [SD] change 0.59,P= .015), and non-HDL-C (OR per 1SD change 1.53,P= .04) were significantly associated with the presence of plaques. The cIMT correlated with obesity parameters, BP, apoB, glucose, high-sensitivity C-reactive protein, creatinine, γ-glutamyl transpeptidase, and alanine transaminase (P< .001). Regression analysis revealed that cIMT was significantly associated with apoB, SBP, and WHR. These results confirm the role of apoB-containing lipoproteins and low HDL-C with the presence of carotid plaques and apoB, BP, and WHR with cIMT., (© The Author(s) 2015.)
- Published
- 2016
- Full Text
- View/download PDF