1. Self-reported sleep duration and napping, cardiac risk factors and markers of subclinical vascular disease: cross-sectional study in older men.
- Author
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Zonoozi S, Ramsay SE, Papacosta O, Lennon L, Ellins EA, Halcox JPJ, Whincup PH, and Goya Wannamethee S
- Subjects
- Aged, Aged, 80 and over, Asymptomatic Diseases, Atherosclerosis complications, Atherosclerosis diagnostic imaging, Biomarkers blood, Carotid Intima-Media Thickness, Cross-Sectional Studies, Disorders of Excessive Somnolence complications, Disorders of Excessive Somnolence physiopathology, Forced Expiratory Volume, Heart Failure diagnosis, Heart Failure physiopathology, Humans, Male, Natriuretic Peptide, Brain blood, Peptide Fragments blood, Pulse Wave Analysis, Risk Factors, Self Report, Time Factors, Troponin blood, Vascular Stiffness, von Willebrand Factor metabolism, Atherosclerosis physiopathology, Blood Glucose metabolism, Disorders of Excessive Somnolence blood, Glycated Hemoglobin metabolism, Insulin blood, Sleep physiology
- Abstract
Studyobjectives: Daytime sleep has been associated with increased risk of cardiovascular disease and heart failure (HF), but the mechanisms remain unclear. We have investigated the association between daytime and night-time sleep patterns and cardiovascular risk markers in older adults including cardiac markers and subclinical markers of atherosclerosis (arterial stiffness and carotid intima-media thickness (CIMT))., Methods: Cross-sectional study of 1722 surviving men aged 71-92 examined in 2010-2012 across 24 British towns from a prospective study initiated in 1978-1980. Participants completed a questionnaire and were invited for a physical examination. Men with a history of heart attack or HF (n=251) were excluded from the analysis., Results: Self-reported daytime sleep duration was associated with higher fasting glucose and insulin levels (p=0.02 and p=0.01, respectively) even after adjustment for age, body mass index, physical activity and social class. Compared with those with no daytime sleep, men with daytime sleep >1 hour, defined as excessive daytime sleepiness (EDS), had a higher risk of raised N-terminal pro-brain natriuretic peptide of ≥400 pg/mL, the diagnostic threshold for HF (OR (95% CI)=1.88 (1.15 to 3.1)), higher mean troponin, reduced lung function (forced expiratory volume in 1 s) and elevated von Willebrand factor, a marker of endothelial dysfunction. However, EDS was unrelated to CIMT and arterial stiffness. By contrast, night-time sleep was only associated with HbA1c (short or long sleep) and arterial stiffness (short sleep)., Conclusions: Daytime sleep duration of >1 hour may be an early indicator of HF., Competing Interests: Competing interests: None declared., (© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)
- Published
- 2017
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