1. The association of Sort1 expression with LDL subfraction and inflammation in patients with coronary artery disease.
- Author
-
Atak M, Sevim Nalkiran H, Bostan M, and Uydu HA
- Subjects
- Humans, Adaptor Proteins, Vesicular Transport genetics, Lipoproteins, Inflammation, Coronary Artery Disease, Atherosclerosis
- Abstract
Background: Controversial effect of sortilin on lipoprotein metabolism in the development of atherosclerosis reveals the need for more extensive research., Objectives: The aim of this study was to investigate the association between Sort1 gene expression and lipids, lipoprotein subfractions, and inflammation in CAD., Methods: The study population included 162 subjects with CAD and 49 healthy individuals. The Sort1 gene expression level was determined by qRT-PCR using Human Sortilin TaqMan Gene Expression Assays. Lipoprotein subclasses were analysed by the Lipoprint system. Serum levels of apolipoprotein and CRP were measured by autoanalyzer., Results: Sort1 gene expression and atherogenic subfraction (SdLDL) levels were significantly higher ( p < 0.001) while atheroprotective subfraction (LbLDL) was lower in the subjects with CAD ( p < 0.050). Also, increased Sort1 gene expression levels were observed in those with higher CRP values., Conclusions: Our findings reveal that the high Sort1 gene expression has a prominent linear relationship with both the atherogenic LDL phenotype and proinflammation, thereby might contribute to the occurrence of CAD.
- Published
- 2024
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