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Start Over Author "Insirello L" Topic astrocytes
3 results on '"Insirello L"'

1. Effect of growth factors on macromolecular synthesis in primary rat astroglial cell cultures.

Author

Avola R, Ragusa N, Reale S, Costa A, Insirello L, and Giuffrida Stella AM

Subjects
Amino Acids metabolism, Animals, Animals, Newborn, Astrocytes drug effects, Cells, Cultured, Epidermal Growth Factor pharmacology, Fibroblast Growth Factor 2 pharmacology, Insulin pharmacology, Kinetics, Rats, Thymidine metabolism, Transferrin pharmacology, Tritium, Uridine metabolism, Astrocytes metabolism, Brain metabolism, DNA biosynthesis, Growth Substances pharmacology, Insulin-Like Growth Factor I pharmacology, Nerve Tissue Proteins biosynthesis, RNA biosynthesis
Published
1993
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2. Effect of EGF on DNA labeling in rat cerebellar immature astrocytes maintained under different culture conditions. Presence or absence of polylysine, serum, or both.

Author

Avola R, Magrì G, Ingrao F, Insirello L, Carpano P, Nicoletti VG, Condorelli DF, Ragusa N, and Giuffrida Stella AM

Subjects
Animals, Cells, Cultured, Cellular Senescence, Cerebellum cytology, Culture Media, Glial Fibrillary Acidic Protein metabolism, Rats, Vimentin metabolism, Astrocytes metabolism, Blood Physiological Phenomena, Cerebellum metabolism, DNA metabolism, Epidermal Growth Factor pharmacology, Polylysine pharmacology
Published
1991
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3. Effect of trophic factors, released after hippocampal injury, on astroglial cell proliferation.

Author

Condorelli DF, Belluardo N, Avola R, Insirello L, Carpano P, Nicoletti V, Bindoni M, and Giuffrida Stella AM

Subjects
Animals, Astrocytes drug effects, Astrocytes metabolism, Cell Division drug effects, Glutamate-Ammonia Ligase metabolism, Hippocampus metabolism, Ibotenic Acid, Male, Rats, Rats, Inbred Strains, Thymidine, Astrocytes cytology, Growth Substances metabolism, Hippocampus injuries
Abstract

An increase in astrocyte mitogenic factors and in some specific astroglial enzymatic activities after neuronal injury has been observed. Our study is concerned with the effect of the intracerebral administration of ibotenic acid (IBO) into the rat hippocampus. IBO injection causes a selective degeneration of neurons while sparing afferent fibers. We observed a transient increase in glutamine synthetase activity, a well-known astroglial marker, reaching a peak at 9-15 days after injury in lesioned hippocampus. We investigated the presence of astrocyte mitogenic factors at various times after toxin injection. Crude extracts, prepared from lesioned hippocampi 4, 9, and 14 days after IBO injection, were tested for the ability to stimulate [methyl-3H]thymidine incorporation into rat astroglial cell cultures. Crude extracts prepared 9 and 14 days after IBO injection showed a higher mitogenic activity compared to extracts prepared 4 days after lesion. Mitogenic activity of injured brain extracts was suppressed by heat inactivation (100 degrees C for 10 min).

Published
1989
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