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2 results on '"Maiz L"'

1. Prevalence of modifiable factors limiting treatment efficacy of poorly controlled asthma patients: EFIMERA observational study.

Author

Ribó P, Molina J, Calle M, Maiz L, Campo C, Rytilä P, Plaza V, and Valero A

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Anti-Asthmatic Agents administration & dosage, Anti-Asthmatic Agents therapeutic use, Cross-Sectional Studies, Dry Powder Inhalers, Female, Humans, Male, Medication Adherence statistics & numerical data, Middle Aged, Nebulizers and Vaporizers, Prevalence, Risk Factors, Treatment Outcome, Young Adult, Asthma drug therapy
Abstract

Several modifiable factors leading to poor asthma control have been described. We aimed to determine the proportion of patients with inadequate treatment, adherence to it, or critical mistakes with inhaler technique, and their impact on asthma control. We conducted a cross-sectional multicenter observational study including asthma patients referred from primary to specialist care for the first time. Data collected were adequate prescription according to guidelines, treatment adherence, and disease control. Of the 1682 patients (age 45 ± 17 years, 64.6% men), 35.9% showed inadequate prescription, 76.8% low adherence, and 17% critical mistakes with inhaler technique, with significantly less critical mistakes among Easyhaler users versus other dry powder inhaler users (10.3 versus 18.4%; p < 0.05). Factors related to bad asthma control were inadequate prescription (OR: 3.65), non-adherence to treatment (OR: 1.8), and inhaler misuse (OR: 3.03). A higher number of risk factors were associated with a higher probability of having badly controlled asthma.

Published
2020
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2. Impact of Pseudomonas aeruginosa Infection on Patients with Chronic Inflammatory Airway Diseases

Author

Garcia-Clemente, M, de la Rosa, D, Maiz, L, Giron, R, Blanco, M, Olveira, C, Canton, R, Martinez-Garcia, MA, and [Garcia-Clemente,M] Pneumology Department, Hospital Universitario Central de Asturias, Oviedo, Spain. [de la Rosa,D] Pneumology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. [Máiz,L] Servicio de Neumología, Unidad de Fibrosis Quística, Bronquiectasias e Infección Bronquial Crónica, Hospital Ramón y Cajal, Madrid, Spain. [Girón,R] Pneumology Department, Hospital Univesitario la Princesa, Madrid, Spain. [Blanco,M] Servicio de Neumología, Hospital Universitario A Coruña, A Coruña, Spain. [Olveira,S] Servicio de Neumología, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain. [Canton,R] Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain. [Martinez-García,MA] Pneumology Department, Universitary and Polytechnic La Fe Hospital, Valencia, Spain. [Martinez-García,MA] Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.

Subjects
Phenomena and Processes::Genetic Phenomena::Phenotype [Medical Subject Headings], Diseases::Respiratory Tract Diseases::Bronchial Diseases::Asthma [Medical Subject Headings], Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Aerobic Bacteria::Gram-Negative Aerobic Rods and Cocci::Pseudomonadaceae::Pseudomonas::Pseudomonas aeruginosa [Medical Subject Headings], Anatomy::Respiratory System [Medical Subject Headings], Phenomena and Processes::Microbiological Phenomena::Drug Resistance, Microbial [Medical Subject Headings], Chronic bronchial infection, Cystic fibrosis, Asthma, Bronchiectasis, respiratory tract diseases, Fibrosis quística, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Diseases::Respiratory Tract Diseases::Lung Diseases::Cystic Fibrosis [Medical Subject Headings], Bronquiectasia, Pseudomonas aeruginosa, COPD, Enfermedad pulmonar obstructiva crónica, Diseases::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Obstructive::Pulmonary Disease, Chronic Obstructive [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings], COPD, Pseudomonas aeruginosa, asthma, bronchiectasis, chronic bronchial infection, cystic fibrosis, Asma, Bronquitis crónica, Diseases::Respiratory Tract Diseases::Bronchial Diseases::Bronchiectasis [Medical Subject Headings]
Abstract

Pseudomonas aeruginosa ( P. aeruginosa ) is a ubiquitous and opportunistic microorganism and is considered one of the most significant pathogens that produce chronic colonization and infection of the lower respiratory tract, especially in people with chronic inflammatory airway diseases such as asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and bronchiectasis. From a microbiological viewpoint, the presence and persistence of P. aeruginosa over time are characterized by adaptation within the host that precludes any rapid, devastating injury to the host. Moreover, this microorganism usually develops antibiotic resistance, which is accelerated in chronic infections especially in those situations where the frequent use of antimicrobials facilitates the selection of "hypermutator P. aeruginosa strain". This phenomenon has been observed in people with bronchiectasis, CF, and the "exacerbator" COPD phenotype. From a clinical point of view, a chronic bronchial infection of P. aeruginosa has been related to more severity and poor prognosis in people with CF, bronchiectasis, and probably in COPD, but little is known on the effect of this microorganism infection in people with asthma. The relationship between the impact and treatment of P. aeruginosa infection in people with airway diseases emerges as an important future challenge and it is the most important objective of this review.

Published
2020

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