Search

Your search keyword '"Julie Herbstman"' showing total 3 results
Start Over Author "Julie Herbstman" Topic asthma
3 results on '"Julie Herbstman"'

1. Association of Severe Bronchiolitis during Infancy with Childhood Asthma Development: An Analysis of the ECHO Consortium

Author

Makiko Nanishi, Aruna Chandran, Xiuhong Li, Joseph B. Stanford, Akram N. Alshawabkeh, Judy L. Aschner, Dana Dabelea, Anne L. Dunlop, Amy J. Elliott, James E. Gern, Tina Hartert, Julie Herbstman, Gurjit K. Khurana Hershey, Alison E. Hipwell, Margaret R. Karagas, Catherine J. Karr, Leslie D. Leve, Augusto A. Litonjua, Cindy T. McEvoy, Rachel L. Miller, Emily Oken, T. Michael O’Shea, Nigel Paneth, Scott T. Weiss, Robert O. Wright, Rosalind J. Wright, Kecia N. Carroll, Xueying Zhang, Qi Zhao, Edward Zoratti, Carlos A. Camargo, and Kohei Hasegawa

Subjects
asthma, bronchiolitis, children, cohort, generalizability, heterogeneity, Biology (General), QH301-705.5
Abstract

Objective: Many studies have shown that severe (hospitalized) bronchiolitis during infancy is a risk factor for developing childhood asthma. However, the population subgroups at the highest risk remain unclear. Using large nationwide pediatric cohort data, namely the NIH Environmental influences on Child Health Outcomes (ECHO) Program, we aimed to quantify the longitudinal relationship of bronchiolitis hospitalization during infancy with asthma in a generalizable dataset and to examine potential heterogeneity in terms of major demographics and clinical factors. Methods: We analyzed data from infants (age Results: The analytic cohort consisted of 11,762 infants, 10% of whom had bronchiolitis hospitalization. Overall, 15% subsequently developed asthma. In the Cox proportional hazards model adjusting for 10 patient-level factors, compared with the no-bronchiolitis hospitalization group, the bronchiolitis hospitalization group had a significantly higher rate of asthma (14% vs. 24%, HR = 2.77, 95%CI = 2.24–3.43, p < 0.001). There was significant heterogeneity by race and ethnicity (Pinteraction = 0.02). The magnitude of the association was greater in non-Hispanic White (HR = 3.77, 95%CI = 2.74–5.18, p < 0.001) and non-Hispanic Black (HR = 2.39, 95%CI = 1.60–3.56; p < 0.001) infants, compared with Hispanic infants (HR = 1.51, 95%CI = 0.77–2.95, p = 0.23). Conclusions: According to the nationwide cohort data, infants hospitalized with bronchiolitis are at a higher risk for asthma, with quantitative heterogeneity in different racial and ethnic groups.

Published
2022
Full Text
View/download PDF

2. Association of Severe Bronchiolitis during Infancy with Childhood Asthma Development: An Analysis of the ECHO Consortium

Author

Makiko Nanishi, Aruna Chandran, Xiuhong Li, Joseph B. Stanford, Akram N. Alshawabkeh, Judy L. Aschner, Dana Dabelea, Anne L. Dunlop, Amy J. Elliott, James E. Gern, Tina Hartert, Julie Herbstman, Gurjit K. Khurana Hershey, Alison E. Hipwell, Margaret R. Karagas, Catherine J. Karr, Leslie D. Leve, Augusto A. Litonjua, Cindy T. McEvoy, Rachel L. Miller, Emily Oken, T. Michael O’Shea, Nigel Paneth, Scott T. Weiss, Robert O. Wright, Rosalind J. Wright, Kecia N. Carroll, Xueying Zhang, Qi Zhao, Edward Zoratti, Carlos A. Camargo, and Kohei Hasegawa

Subjects
asthma, bronchiolitis, children, cohort, generalizability, heterogeneity, Medicine (miscellaneous), General Biochemistry, Genetics and Molecular Biology
Abstract

Objective: Many studies have shown that severe (hospitalized) bronchiolitis during infancy is a risk factor for developing childhood asthma. However, the population subgroups at the highest risk remain unclear. Using large nationwide pediatric cohort data, namely the NIH Environmental influences on Child Health Outcomes (ECHO) Program, we aimed to quantify the longitudinal relationship of bronchiolitis hospitalization during infancy with asthma in a generalizable dataset and to examine potential heterogeneity in terms of major demographics and clinical factors. Methods: We analyzed data from infants (age

Published
2023
Full Text
View/download PDF

3. Expression quantitative trait locus fine mapping of the 17q12–21 asthma locus in African American children: a genetic association and gene expression study

Author

Carole Ober, Chris G McKennan, Kevin M Magnaye, Matthew C Altman, Charles Washington, Catherine Stanhope, Katherine A Naughton, Mario G Rosasco, Leonard B Bacharier, Dean Billheimer, Diane R Gold, Lisa Gress, Tina Hartert, Suzanne Havstad, Gurjit K Khurana Hershey, Brian Hallmark, D Kyle Hogarth, Daniel J Jackson, Christine C Johnson, Meyer Kattan, Robert F Lemanske, Susan V Lynch, Eneida A Mendonca, Rachel L Miller, Edward T Naureckas, George T O'Connor, Christine M Seroogy, Ganesa Wegienka, Steven R White, Robert A Wood, Anne L Wright, Edward M Zoratti, Fernando D Martinez, Dennis Ownby, Dan L Nicolae, Albert M Levin, James E Gern, Niek Achten, John Ainsworth, Nonna Akkerman, Elizabeth Anderson, Larry J. Anderson, Howard Andrews, Elizabeth Armagost, Mary Ann Aubuchon, Julia Bach, Leonard Bacharier, Kathrine L. Barnes, Charles Barone, Irma Bauer, Paloma Beamer, Patrice Becker, Alyssa Bednarek, Stacey Bellemore, Casper G. Bendixsen, Jocelyn M. Biagini Myers, Christine Billstrand, Geraldine Birg, Shirley Blocki, Gordon Bloomberg, Kevin Bobbitt, Yury Bochkov, Karen Bourgeois, Homer Boushey, Rebecca Brockman-Schneider, Steven M. Brunwasser, Richard Budrevich, Jeffrey W. Burkle, William Busse, Agustin Calatroni, Janice Campbell, Kirsten Carlson-Dakes, Andrea Cassidy-Bushrow, James D. Chappell, Deborah Chasman, Teresa M. Chipps, Tatiana Chirkova, Deanna Cole, Alexandra Connolly, Michelle Cootauco, Kaitlin Costello, Philip Couch, Brent Coull, Mark Craven, Gina Crisafi, William Cruikshank, Kristi Curtsinger, Adnan Custovic, Suman R. Das, Douglas DaSilva, Soma Datta, Brent Davidson, Lydia De La Ossa, Mark DeVries, Qian Di, Samara Dixon, Erin Donnerbauer, Marian Dorst, Susan Doyle, Amy Dresen, William D. Dupont, Janet Durrange, Heidi Erickson, Michael D. Evans, Jerel Ezell, Leanna Farnham, Roxanne Filardo-Collins, Salvatore Finazzo, Zachary Flege, Conner Fleurat, Heather Floerke, Dorothy Floerke, Terry Foss, Angela Freie, Wayne Frome, Samantha Fye, Lisa Gagalis, Rebecca Gammell, Ronald E. Gangnon, James E. Ge, Tebeb Gebretsadik, Peter Gergen, James E. Gern, Heike Gibson, Edlira Gjerasi, Diane R. Gold, Nicole Gonzalez, Kayla Goodman, Kristine Grindle, Taylor Groeschen, Marilyn Halonen, Jaime Hart, Tina V. Hartert, Patrick Heinritz, Sharon Hensley Alford, Julie Herbstman, Kellie Hernandez, Lori Hoepner, Daniel J. Jackson, Samadhan J. Jadhao, Katy Jaffee, Peter James, Jacqueline Jezioro, Marcia Jimenez Pescador, Christine C. Johnson, Tara Johnson, Camille Johnson, Amelia Jones, Kyra Jones, Paul Jones, Carolina Jordan, Christine LM Joseph, Kristina Keidel, Matthew C. Keifer, Rick Kelley, Gurgit K. Khurana Hershey, Haejin Kim, Itai Kloog, Tammy Kronenwetter Koepel, Clint Koerkenmeier, Laura Ladick, Carin Lamm, Emma Larkin, Howard Lederman, Aviva Lee-Parritz, Stephanie Leimenstoll, Robert F. Lemanske, Jr., Grace K. LeMasters, Albert M. Levin, Jessica Levine, Xinhua Liu, Zhouwen Liu, Silvia Lopez, Nathan Lothrop, Stephanie Lovinsky-Desir, Nicholas Lukacs, Susan Lynch, Christian Lynch, Erik Mann, Jennifer Martin, Lisa Martin, Fernando D. Martinez, Elizabeth Matsui, Katherine McCauley, Megan Mccollum, Judith McCullough, Chris G. McKennon, Jennifer Meece, Eneida Mendonca, Lance Mikus, Rachel L. Miller, Patricia Minton, Herman Mitchell, Vicki Moon, Paul E. Moore, Wayne Morgan, Valerie Morgan, David Morgan, Liza Murrison, Charlotte Nicholas, Daniel Nicolae, Adam Nunez, George O'Connor, Sharon O'Toole, Brent F. Olson, Irene Ong, Sarah Osmundson, Tressa Pappas, Frederica Perera, Matthew Perzanowski, Edward Peterson, Marcela Pierce, Penny Price-Johnson, Victoria Rajamanickam, Judyth Ramirez, Kimberly Ray, Megan Renneberg, Weeberb Requia, Kylie Riley, Janelle Rivera, Neisha Rivers, Kathy Roberg, Theresa Rogers, Christian Rosas-Salazar, Pat Russell, Patrick H. Ryan, Yoel Sadovsky, Lisa Salazar, Hugh Sampson, Megan Sandel, Nathan Schoettler, Joel Schwartz, Dena Scott, Christine M. Seroogy, Renee Sharp, Meghan H. Shilts, Steve Sigelman, Anne Marie Singh, Alexandra Sitarik, Ernestine Smartt, Ronald Sorkness, Christine Sorkness, Amber Spangenberg, Rhoda Sperling, David Spies, Debra A. Stern, Brandy Stoffel, R. Stokes Peebles, Gina Stouffer, Cathey Strauchman Boyer, Caitlin Suddeuth, Umberto Tachinardi, Deliang Tang, Zhengzheng Tang, Jena Tate, William Taylor, Krista Tensing, Elizabeth Tesson, Kathy Thompson, Emma Thompson, Christopher Tisler, Alkis Togias, Kedir Turi, Victoria Turner, Marina Tuzova, Jeffrey J. VanWormer, Cynthia M. Visness, Rose Vrtis, Anthony Wahlman, Lena Wang, Karen Wells, William Wentworth-Sheilds, Lisa Wheatley, Nitsa Whitney, L. Keoki Williams, Frank Witter, Christopher Wolfe, Robert A. Wood, Kimberley Woodcroft, Kim B. Woodward, Anne L. Wright, Rosalind Wright, Pingsheng Wu, Melissa Yaeger, Perri Yaniv, Antonella Zanobetti, Shirley Zhang, Patricia Zook, Edward M. Zoratti, and Academic Medical Center

Subjects
Pulmonary and Respiratory Medicine, Male, Candidate gene, Linkage disequilibrium, Genotype, Quantitative Trait Loci, Single-nucleotide polymorphism, Locus (genetics), Quantitative trait locus, Polymorphism, Single Nucleotide, Linkage Disequilibrium, White People, 03 medical and health sciences, 0302 clinical medicine, Medicine, Humans, Genetic Predisposition to Disease, 030212 general & internal medicine, Allele, Child, Genetic Association Studies, Genetic association, Genetics, business.industry, Gene Expression Profiling, Membrane Proteins, Epithelial Cells, Asthma, United States, Neoplasm Proteins, Black or African American, 030228 respiratory system, Expression quantitative trait loci, Leukocytes, Mononuclear, Female, business, Chromosomes, Human, Pair 17
Abstract

Background: African ancestry is associated with a higher prevalence and greater severity of asthma than European ancestries, yet genetic studies of the most common locus associated with childhood-onset asthma, 17q12–21, in African Americans have been inconclusive. The aim of this study was to leverage both the phenotyping of the Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium, and the reduced linkage disequilibrium in African Americans, to fine map the 17q12–21 locus. Methods: We first did a genetic association study and meta-analysis using 17q12–21 tag single-nucleotide polymorphisms (SNPs) for childhood-onset asthma in 1613 European American and 870 African American children from the CREW consortium. Nine tag SNPs were selected based on linkage disequilibrium patterns at 17q12–21 and their association with asthma, considering the effect allele under an additive model (0, 1, or 2 effect alleles). Results were meta-analysed with publicly available summary data from the EVE consortium (on 4303 European American and 3034 African American individuals) for seven of the nine SNPs of interest. Subsequently, we tested for expression quantitative trait loci (eQTLs) among the SNPs associated with childhood-onset asthma and the expression of 17q12–21 genes in resting peripheral blood mononuclear cells (PBMCs) from 85 African American CREW children and in upper airway epithelial cells from 246 African American CREW children; and in lower airway epithelial cells from 44 European American and 72 African American adults from a case-control study of asthma genetic risk in Chicago (IL, USA). Findings: 17q12–21 SNPs were broadly associated with asthma in European Americans. Only two SNPs (rs2305480 in gasdermin-B [GSDMB] and rs8076131 in ORMDL sphingolipid biosynthesis regulator 3 [ORMDL3]) were associated with asthma in African Americans, at a Bonferroni-corrected threshold of p

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results