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4 results on '"Jing-Yi Hou"'

1. A bio-adhesion nanogel particle as an anti-inflammation agent for efficient aerosol inhalation therapy to asthma

Author

Yi-Bing Chen, Jing-Yi Hou, Xiao-Yue Yue, Yan-Qiu Wang, Jian Huang, Dong Xu, Yuan-Lu Cui, and Qiangsong Wang

Subjects
Nanogel particles, Ultrasonic aerosol inhalation, Icariin, Asthma, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

Asthma is a heterogeneous respiratory disease characterized by airway inflammation occurring in the bronchus. Direct delivery of targeted treatments to the bronchus for asthma has the potential to optimize therapeutic efficacy. Inhaled corticosteroids are cornerstone therapy for persistent asthma, however, there remain challenges in designing effective formulations for the inhaled route and minimizing long-term corticosteroid side effects. Here, a nanogel delivery system with good bio-adhesion based on alginate crosslinked with zinc ions was designed. The prepared alginate nanogel particles (ALG-NPs) effectively delivered icariin (ICA) which possesses anti-inflammatory and antioxidant activities, to the bronchus through ultrasonic aerosol inhalation, thereby ameliorating asthmatic symptoms and attenuating bronchial inflammation. The ALG-NPs exhibited favorable biological safety and could be deposited in the bronchus to control the release of ICA, enabling targeted treatment of asthma. In addition, ICA loaded ALG-NPs significantly reduced airway inflammation by modulating key targets associated with asthm (Th1 transcription factor and Th2 transcription factor) while also inducing eosinophilic apoptosis by regulating the Bax/Bcl-2 ratio expression. This study suggests that the ultrasonic aerosol inhalation of ICA loaded ALG-NPs was a promising strategy of treating asthma.

Published
2024
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2. Integration of transcriptomics and system pharmacology to reveal the therapeutic mechanism underlying Qingfei Xiaoyan Wan to treat allergic asthma

Author

Guanwei Fan, Jing-Yi Hou, Dan-Dan Shang, Shu Liu, Jia-Rong Wu, Dong Xu, Yi-Bing Chen, and Yuan-Lu Cui

Subjects
Ovalbumin, medicine.medical_treatment, Pharmacology, 03 medical and health sciences, Mice, 0302 clinical medicine, Immune system, Drug Discovery, medicine, Hypersensitivity, CXCL10, Animals, Anti-Asthmatic Agents, Lung, 030304 developmental biology, Asthma, 0303 health sciences, Mice, Inbred BALB C, biology, business.industry, Smooth muscle contraction, medicine.disease, CXCL1, CXCL2, Cytokine, Gene Expression Regulation, 030220 oncology & carcinogenesis, biology.protein, Cytokines, Female, business, Transcriptome, Drugs, Chinese Herbal
Abstract

Ethnopharmacological relevance Asthma is a chronic inflammatory disease, characterized by airway inflammation, hyperresponsiveness, and bronchial smooth muscle contraction. Qingfei Xiaoyan Wan (QFXYW), a traditional Chinese formula, has been shown to exert anti-asthma effects and immune response in multiple diseases. Aim of this study In this study, we evaluated the therapeutic mechanism of QFXYW in the suppression of allergic asthma by integrating of transcriptomics and system pharmacology. Materials and methods BALB/c mice were sensitized with ovalbumin (OVA) to establish the allergic asthma model, and its success was confirmed with behavioral observations. Lung histopathological analysis, inflammatory pathology scores, transcription factors were used to evaluate the effects of QFXYW on allergic asthma. The therapeutic mechanism of QFXYW in treating allergic asthma through integrated transcriptomics and system pharmacology was then determined: hub genes were screened out by topological analysis and functional enrichment analysis were performed to identify key signaling pathway. Subsequently, quantitative RP-PCR and protein array were performed to detect the mRNA of hub genes and to predict the key pathway in OVA-induced allergic asthma, respectively. Results Our results demonstrated that QFXYW could significantly attenuate inflammatory cell infiltration, mucus secretion, and epithelial damage. The transcriptomics analysis found the six hub genes with the highest values- CXCL10, CXCL2, CXCL1, IL-6, CCL-5, and CCL-4 were screened out. Functional enrichment analysis showed that the differentially expressed genes (DEGs) were mainly enriched in the inflammatory response and cytokine signaling pathway. Moreover, the quantitative RT-PCR verification experiment found the CXCL2 and CXCL1 were significantly suppressed after treatment with QFXYW. The results of protein array showed that QFXYW inhibited the multi-cytokines of OVA-induced allergic asthma via cytokine signaling pathway. Conclusions QFXYW may have mediated OVA-induced allergic asthma mainly through the hub genes CXCL2, CXCL1, and the cytokine signaling pathway. This finding will offer a novel strategy to explore effective and safe mechanism of Traditional Chinese Medicine (TCM) formula to treat allergic asthma.

Published
2021

3. Tianjin University of Traditional Chinese Medicine Researchers Broaden Understanding of Asthma (A bio-adhesion nanogel particle as an anti-inflammation agent for efficient aerosol inhalation therapy to asthma).

Subjects
CHINESE medicine, RESPIRATORY therapy, RESEARCH personnel, ASTHMA, BRONCHIAL diseases
Abstract

Researchers from Tianjin University of Traditional Chinese Medicine have developed a nanogel delivery system for the treatment of asthma. The system, based on alginate crosslinked with zinc ions, effectively delivered an anti-inflammatory and antioxidant compound called icariin (ICA) to the bronchus through ultrasonic aerosol inhalation. The nanogel particles exhibited good bio-adhesion and could control the release of ICA, leading to the amelioration of asthmatic symptoms and attenuation of bronchial inflammation. The study suggests that this approach could be a promising strategy for treating asthma. [Extracted from the article]

Published
2024

4. Tianjin University of Traditional Chinese Medicine Researchers Broaden Understanding of Asthma (A bio-adhesion nanogel particle as an anti-inflammation agent for efficient aerosol inhalation therapy to asthma)

Subjects
Inflammation, Medicine, Chinese, Asthma, Health, Tianjin University
Abstract

2024 MAR 4 (NewsRx) -- By a News Reporter-Staff News Editor at Respiratory Therapeutics Week -- Investigators publish new report on asthma. According to news reporting originating from Tianjin, People's [...]

Published
2024

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