1. Context-dependent function of TSLP and IL-1β in skin allergic sensitization and atopic march.
- Author
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Segaud J, Yao W, Marschall P, Daubeuf F, Lehalle C, German B, Meyer P, Hener P, Hugel C, Flatter E, Guivarch M, Clauss L, Martin SF, Oulad-Abdelghani M, and Li M
- Subjects
- Allergens, Animals, Mice, Skin, Thymic Stromal Lymphopoietin, Asthma complications, Cytokines metabolism, Dermatitis, Atopic genetics, Dermatitis, Atopic metabolism, Interleukin-1beta metabolism
- Abstract
Atopic diseases, including atopic dermatitis (AD) and asthma, affect a large proportion of the population, with increasing prevalence worldwide. AD often precedes the development of asthma, known as the atopic march. Allergen sensitization developed through the barrier-defective skin of AD has been recognized to be a critical step leading to asthma, in which thymic stromal lymphopoietin (TSLP) was previously shown to be critical. In this study, using a laser-assistant microporation system to disrupt targeted skin layers for generating micropores at a precise anatomic depth of mouse skin, we model allergen exposure superficially or deeply in the skin, leading to epicutaneous sensitization or dermacutaneous sensitization that is associated with a different cytokine microenvironment. Our work shows a differential requirement for TSLP in these two contexts, and identifies an important function for IL-1β, which is independent of TSLP, in promoting allergen sensitization and subsequent allergic asthma., (© 2022. The Author(s).)
- Published
- 2022
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