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3. Single nucleotide polymorphism in the MMP-9 gene is associated with susceptibility to develop multiple sclerosis in an Italian case-control study

Author

La Russa, Antonella, Cittadella, Rita, De Marco, Elvira Valeria, Valentino, Paola, Andreoli, Virginia, Trecroci, Francesca, Latorre, Valeria, Gambardella, Antonio, and Quattrone, Aldo

Subjects
*GENETIC regulation, *METALLOPROTEINASES, *MULTIPLE sclerosis, *DISEASE susceptibility, *CASE studies, *MEDICAL care, *GENETIC polymorphisms, *PATIENTS
Abstract

Abstract: To investigate the role of the matrix metalloproteinase-9 gene (MMP-9) in multiple sclerosis (MS), we analyzed the functional −1562C/T and −90 (CA)n repeat polymorphisms in 243 Italian patients with MS and 173 healthy controls. A significant increase of the −1562T allele carriers was found in patients with MS compared to controls. Moreover, haplotype analysis showed that the haplotype formed by the −1562T allele and the L allele ((CA)≤20) was over-represented in patients with MS versus controls. These results suggest that a genetic polymorphism of the MMP-9 promoter region may influence the susceptibility to MS. [ABSTRACT FROM AUTHOR]

Published
2010
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